2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis DNA Alkylator/Crosslinker
  4. Imifoplatin

Imifoplatin  (Synonyms: PT-112)

Cat. No.: HY-109146 Purity: ≥95.0%
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Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.

For research use only. We do not sell to patients.

Imifoplatin Chemical Structure

Imifoplatin Chemical Structure

CAS No. : 1339960-28-9

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Based on 1 publication(s) in Google Scholar

Imifoplatin Related Antibodies

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Description

Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity[1][2][3].

In Vitro

Imifoplatin (5–20 µM, 72 hours) shows dose-dependent proliferation inhibition in HCT116 cells[2].
Imifoplatin (10 µM, 24 hours) significantly induces apoptosis in HCT116 cells[2].
Imifoplatin (0.287–222.14 µM, 72 hours) significantly inhibits proliferation in CT26 cells[2].
Imifoplatin (2–10 μM, 24–72 hours) has notable selectivity, showing strong inhibition of glycolytic tumor cells with mtDNA mutations[3].
Imifoplatin (10 μM, 48–72 hours) significantly increases mtROS, especially in glycolytic L929dt and Cybrid cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imifoplatin Related Antibodies

Cell Viability Assay[3]

Cell Line: Mouse fibroblast L929, mtDNA mutant L929dt, and Cybrid cells
Concentration: 2, 6, 10 μM
Incubation Time: 24–72 hours
Result: Inhibited L929dt and Cybrid cells by about 80% after 48 hours, while inhibition in OXPHOS-competent L929 cells was lower.

Cell Proliferation Assay[2]

Cell Line: HCT116 (human colorectal cancer cells)
Concentration: 5, 10, 20 µM
Incubation Time: 72 hours
Result: Significantly inhibited cell proliferation at higher concentrations.

Apoptosis Analysis[2]

Cell Line: HCT116 (human colorectal cancer cells)
Concentration: 10 µM
Incubation Time: 24 hours
Result: Increased proportions of early and late apoptotic cells.
In Vivo

Imifoplatin (90 mg/kg, i.v., once weekly for 5 weeks) demonstrates potent antitumor immune effects in the CT26 xenograft model[2].
Imifoplatin (90 mg/kg, i.v., once weekly for 7 weeks) shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade (Avelumab (HY-108730))[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 colorectal carcinoma xenograft model in C57BL/6J mice[2]
Dosage: 90 mg/kg
Administration: Intravenous injection (i.v.), once weekly for 7 weeks
Result: Inhibited tumor growth, extended survival; further enhanced survival when combined with PD-1 blockade (Avelumab (HY-108730)).
Animal Model: CT26 colorectal carcinoma xenograft model in BALB/c mice[2]
Dosage: 90 mg/kg
Administration: Intravenous injection (i.v.), once weekly for 5 weeks
Result: Significantly inhibited tumor growth, increased T-cell infiltration, reduced immunosuppressive TAMs.
Clinical Trial
Molecular Weight

485.23

Formula

C6H16N2O7P2Pt
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[P]([O-][Pt+2]1([O-][P]2(O)=O)[NH2][C@@](CCCC3)([H])[C@]3([H])[NH2]1)(O2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 1.25 mg/mL (2.58 mM; Need ultrasonic; DMSO can inactivate Imifoplatin's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0609 mL 10.3044 mL 20.6088 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (258 KB) HNMR (141 KB) CNMR (132 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0609 mL 10.3044 mL 20.6088 mL 51.5220 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Imifoplatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imifoplatin1339960-28-9PT-112PT112PT 112ApoptosisDNA Alkylator/CrosslinkerplatinumphosphaplatinantineoplasticcancerInhibitorinhibitorinhibit

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