1. Anti-infection
  2. HBV
  3. Inarigivir ammonium

Inarigivir ammonium  (Synonyms: ORI-9020 ammonium; SB-9000 ammonium)

Cat. No.: HY-101954A Purity: 99.04%
Data Sheet SDS COA Handling Instructions

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses.

For research use only. We do not sell to patients.

Inarigivir ammonium Chemical Structure

Inarigivir ammonium Chemical Structure

CAS No. : 2172788-92-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 1074 In-stock
Solution
10 mM * 1 mL in DMSO USD 1130 In-stock
Solid
1 mg USD 400 In-stock
5 mg USD 850 In-stock
10 mg USD 1275 In-stock
50 mg USD 2900 In-stock
100 mg USD 3820 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Inarigivir ammonium:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses[1][2].

IC50 & Target

Target: HBV[1].

In Vitro

Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 100 mg/kg.
Administration: IP, daily.
Result: Significantly reduced viral DNA in the liver and shows anti-HBV activity similar ADV positive control.
Clinical Trial
Molecular Weight

604.53

Formula

C20H29N8O10PS

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC1=C(N=CN2[C@@H]3O[C@H](COP(O[C@H]4[C@@H](OC)[C@H](N5C=CC(NC5=O)=O)O[C@@H]4CO)(S)=O)[C@@H](O)C3)C2=NC=N1.N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (165.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (165.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6542 mL 8.2709 mL 16.5418 mL
5 mM 0.3308 mL 1.6542 mL 3.3084 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (165.42 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.04%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.6542 mL 8.2709 mL 16.5418 mL 41.3544 mL
5 mM 0.3308 mL 1.6542 mL 3.3084 mL 8.2709 mL
10 mM 0.1654 mL 0.8271 mL 1.6542 mL 4.1354 mL
15 mM 0.1103 mL 0.5514 mL 1.1028 mL 2.7570 mL
20 mM 0.0827 mL 0.4135 mL 0.8271 mL 2.0677 mL
25 mM 0.0662 mL 0.3308 mL 0.6617 mL 1.6542 mL
30 mM 0.0551 mL 0.2757 mL 0.5514 mL 1.3785 mL
40 mM 0.0414 mL 0.2068 mL 0.4135 mL 1.0339 mL
50 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8271 mL
60 mM 0.0276 mL 0.1378 mL 0.2757 mL 0.6892 mL
80 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.5169 mL
100 mM 0.0165 mL 0.0827 mL 0.1654 mL 0.4135 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Product Name:
Inarigivir ammonium
Cat. No.:
HY-101954A
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