2. Others Immunology/Inflammation Autophagy
  3. Isotope-Labeled Compounds COX Autophagy
  4. Indomethacin-d4

Indomethacin-d4 is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

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Indomethacin-d<sub>4</sub> Chemical Structure

Indomethacin-d4 Chemical Structure

CAS No. : 87377-08-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Indomethacin-d4:

Indomethacin-d4 Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

Indomethacin-d4 is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

IC50 & Target[1]

Human COX-1

18 nM (IC50, in CHO cells)

Human COX-2

26 nM (IC50, in CHO cells)

Molecular Weight

361.81

Formula

C19H12D4ClNO4
CAS No.
Unlabeled CAS

53-86-1
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)CC1=C(C)N(C(C2=C([2H])C([2H])=C(Cl)C([2H])=C2[2H])=O)C3=C1C=C(OC)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Indomethacin-d4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indomethacin-d487377-08-0Indometacin-d4Isotope-Labeled CompoundsCOXAutophagyCyclooxygenaseCOX1COX2autophagicfluxlysosomeNon-steroidalanti-inflammatoryNSAIDInhibitorinhibitorinhibit

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