2. Apoptosis Immunology/Inflammation
  3. Pyroptosis Interleukin Related NOD-like Receptor (NLR)
  4. INF 195

INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury.

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INF 195 Chemical Structure

INF 195 Chemical Structure

CAS No. : 1211379-56-4

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Based on 1 publication(s) in Google Scholar

INF 195 Related Antibodies

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Description

INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1].
IC50 & Target

IL-1β

 

NLRP3

 

In Vitro

INF 195 (0.1-100 μM, 72 h) can inhibit NLRP3 driven macrophage pyroptosis and IL-1 β release[1].
INF 195 (5-10 μM, 10 min) can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1].
INF 195 (10 μ M) is an ethyl ester prodrug of the active metabolite 3- (3- (2-chlorophenyl) propyl) piperidine-1 carboxylic acid, which can penetrate into H9c2 cardiomyocytes and be hydrolyzed into this active metabolite[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

INF 195 Related Antibodies

Cell Cytotoxicity Assay[1].

Cell Line: Human macrophages
Concentration: 0.1–100 μM
Incubation Time: 72 h
Result: Inhibited pyroptosis by about 40%, with an EC50 of 0.15 μM.
Molecular Weight

323.81

Formula

C17H22ClNO3
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(C1CN(C(CCC2=CC=CC=C2Cl)=O)CCC1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (617.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0882 mL 15.4412 mL 30.8823 mL
5 mM 0.6176 mL 3.0882 mL 6.1765 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0882 mL 15.4412 mL 30.8823 mL 77.2058 mL
5 mM 0.6176 mL 3.0882 mL 6.1765 mL 15.4412 mL
10 mM 0.3088 mL 1.5441 mL 3.0882 mL 7.7206 mL
15 mM 0.2059 mL 1.0294 mL 2.0588 mL 5.1471 mL
20 mM 0.1544 mL 0.7721 mL 1.5441 mL 3.8603 mL
25 mM 0.1235 mL 0.6176 mL 1.2353 mL 3.0882 mL
30 mM 0.1029 mL 0.5147 mL 1.0294 mL 2.5735 mL
40 mM 0.0772 mL 0.3860 mL 0.7721 mL 1.9301 mL
50 mM 0.0618 mL 0.3088 mL 0.6176 mL 1.5441 mL
60 mM 0.0515 mL 0.2574 mL 0.5147 mL 1.2868 mL
80 mM 0.0386 mL 0.1930 mL 0.3860 mL 0.9651 mL
100 mM 0.0309 mL 0.1544 mL 0.3088 mL 0.7721 mL
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INF 195 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INF 1951211379-56-4INF195INF-195PyroptosisInterleukin RelatedNOD-like Receptor (NLR)ILcell pyroptosismyocardial ischemiareperfusion injuryInhibitorinhibitorinhibit

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