2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Infigratinib-Boc

Infigratinib-Boc is a derivative of Infigratinib containing a Boc (t-Butyloxy carbonyl) group. Infigratinib is an ATP-competitive pan-FGFR inhibitor.

For research use only. We do not sell to patients.

Infigratinib-Boc Chemical Structure

Infigratinib-Boc Chemical Structure

CAS No. : 2504949-83-9

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5 mg USD 160 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 950 In-stock
100 mg USD 1550 In-stock
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Infigratinib-Boc Related Antibodies

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

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Description

Infigratinib-Boc is a derivative of Infigratinib containing a Boc (t-Butyloxy carbonyl) group. Infigratinib is an ATP-competitive pan-FGFR inhibitor[1].

Molecular Weight

632.54

Formula

C29H35Cl2N7O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=C(Cl)C(OC)=CC(OC)=C1Cl)N(C)C2=CC(NC(C=C3)=CC=C3N4CCN(C(OC(C)(C)C)=O)CC4)=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (158.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5809 mL 7.9046 mL 15.8093 mL
5 mM 0.3162 mL 1.5809 mL 3.1619 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5809 mL 7.9046 mL 15.8093 mL 39.5232 mL
5 mM 0.3162 mL 1.5809 mL 3.1619 mL 7.9046 mL
10 mM 0.1581 mL 0.7905 mL 1.5809 mL 3.9523 mL
15 mM 0.1054 mL 0.5270 mL 1.0540 mL 2.6349 mL
20 mM 0.0790 mL 0.3952 mL 0.7905 mL 1.9762 mL
25 mM 0.0632 mL 0.3162 mL 0.6324 mL 1.5809 mL
30 mM 0.0527 mL 0.2635 mL 0.5270 mL 1.3174 mL
40 mM 0.0395 mL 0.1976 mL 0.3952 mL 0.9881 mL
50 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.7905 mL
60 mM 0.0263 mL 0.1317 mL 0.2635 mL 0.6587 mL
80 mM 0.0198 mL 0.0988 mL 0.1976 mL 0.4940 mL
100 mM 0.0158 mL 0.0790 mL 0.1581 mL 0.3952 mL
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Infigratinib-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Infigratinib-Boc2504949-83-9FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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