2. Immunology/Inflammation Cell Cycle/DNA Damage Apoptosis NF-κB
  3. NO Synthase Topoisomerase Apoptosis NF-κB
  4. iNOS/TopoI-IN-1

iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM).

For research use only. We do not sell to patients.

iNOS/TopoI-IN-1 Chemical Structure

iNOS/TopoI-IN-1 Chemical Structure

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iNOS/TopoI-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All NO Synthase Isoform Specific Products:

View All Isoforms
nNOS iNOS eNOS

View All Topoisomerase Isoform Specific Products:

View All Isoforms
Topoisomerase Topo I Topo II

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM)[1].

IC50 & Target[1]

Topoisomerase I

2.72 μM (Ki)

iNOS

1.49 μM (Ki)

Molecular Weight

886.54

Formula

C34H40AuBrCl2N3OS
SMILES

CC1=CC=C(C)C2=C1N(CCCCCCCCS[Au]C3N(CC(O)C4=CC=CC=C4)C(Cl)=C(Cl)N3C)C5=CC=C(Br)C=C25
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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iNOS/TopoI-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iNOS/TopoI-IN-1NO SynthaseTopoisomeraseApoptosisNF-κBNitric oxide synthasesNOSNuclear factor-κBNuclear factor-kappaBAnti-tumoranti-inflammatoryantioxidantMCF-7MDA MB-231apoptosistopoisomerase IInhibitorinhibitorinhibit

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