Iodophenpropit dihydrobromide

Name: Iodophenpropit dihydrobromide
Brand: MedChemExpress
SKU: HY-107568
Rating: 4.5 (1 reviews)

Cat. No.: HY-107568 Purity: 99.70%: FAQs
Data Sheet SDS COA Handling Instructions

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Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [¹²⁵I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (K_D 0.32 nM).

For research use only. We do not sell to patients.

Iodophenpropit dihydrobromide Chemical Structure

CAS No. : 145196-87-8

Size	Price	Stock	Quantity
1 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 169	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

H₃ Receptor

0.32 nM (Kd)

In Vitro

Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor^[2].
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC₅₀ of 1.57±0.3 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg^[4]
Dosage:	1 μg/kg
Administration:	Administered through intramuscular (i.m.); b.i.d.; for 10 days
Result:	Could influence a detectable antibody response to SRBC.

Molecular Weight

576.13

Formula

C₁₅H₂₁Br₂IN₄S

CAS No.

145196-87-8

Appearance

Solid

Color

White to off-white

SMILES

N=C(SCCCC1=CNC=N1)NCCC2=CC=C(I)C=C2.[H]Br.[H]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 57.6 mg/mL (99.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7357 mL	8.6786 mL	17.3572 mL
5 mM	0.3471 mL	1.7357 mL	3.4714 mL
10 mM	0.1736 mL	0.8679 mL	1.7357 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Jansen FP, et al. The first radiolabeled histamine H3 receptor antagonist, [¹²⁵I]Iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur J Pharmacol. 1992 Jul 7;217(2-3):203-5. [Content Brief]

[2]. Leurs R, et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, Iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br J Pharmacol. 1995 Oct;116(4):2315-21. [Content Brief]

[3]. Allen MC. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Eur J Pharmacol. 1998 Nov 20;361(2-3):261-8. [Content Brief]

[4]. Trivendra Tripathi, et al. In vivo immunomodulatory profile of histamine receptors (H1, H2, H3 and H4): a comparative antagonists study. Asian Pac J Trop Med. 2010 Jun;3(6):465-470.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7357 mL	8.6786 mL	17.3572 mL	43.3930 mL
	5 mM	0.3471 mL	1.7357 mL	3.4714 mL	8.6786 mL
	10 mM	0.1736 mL	0.8679 mL	1.7357 mL	4.3393 mL
	15 mM	0.1157 mL	0.5786 mL	1.1571 mL	2.8929 mL
	20 mM	0.0868 mL	0.4339 mL	0.8679 mL	2.1696 mL
	25 mM	0.0694 mL	0.3471 mL	0.6943 mL	1.7357 mL
	30 mM	0.0579 mL	0.2893 mL	0.5786 mL	1.4464 mL
	40 mM	0.0434 mL	0.2170 mL	0.4339 mL	1.0848 mL
	50 mM	0.0347 mL	0.1736 mL	0.3471 mL	0.8679 mL
	60 mM	0.0289 mL	0.1446 mL	0.2893 mL	0.7232 mL
	80 mM	0.0217 mL	0.1085 mL	0.2170 mL	0.5424 mL