2. Metabolic Enzyme/Protease
  3. Liposome
  4. Ionizable lipid-1

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure.

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Ionizable lipid-1 Chemical Structure

Ionizable lipid-1 Chemical Structure

CAS No. : 2055939-68-7

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5 mg USD 290 In-stock
10 mg USD 460 In-stock
25 mg USD 930 In-stock
50 mg USD 1500 In-stock
100 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ionizable lipid-1:

Ionizable lipid-1 Related Antibodies

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1 Publications Citing Use of MCE Ionizable lipid-1

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  • Purity & Documentation

  • References

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Description

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure[1].

Molecular Weight

919.54

Formula

C58H114N2O5
CAS No.
Appearance

Liquid (Density: 0.914±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 50 mg/mL (54.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0875 mL 5.4375 mL 10.8750 mL
5 mM 0.2175 mL 1.0875 mL 2.1750 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 1.0875 mL 5.4375 mL 10.8750 mL 27.1875 mL
5 mM 0.2175 mL 1.0875 mL 2.1750 mL 5.4375 mL
10 mM 0.1088 mL 0.5438 mL 1.0875 mL 2.7188 mL
15 mM 0.0725 mL 0.3625 mL 0.7250 mL 1.8125 mL
20 mM 0.0544 mL 0.2719 mL 0.5438 mL 1.3594 mL
25 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0875 mL
30 mM 0.0363 mL 0.1813 mL 0.3625 mL 0.9063 mL
40 mM 0.0272 mL 0.1359 mL 0.2719 mL 0.6797 mL
50 mM 0.0218 mL 0.1088 mL 0.2175 mL 0.5438 mL
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Ionizable lipid-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ionizable lipid-12055939-68-7Ionizable lipid1Ionizable lipid 1LiposomeLNPdrug deliveryInhibitorinhibitorinhibit

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