2. Immunology/Inflammation
  3. IRAK
  4. IRAK4-IN-20

IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research.

For research use only. We do not sell to patients.

IRAK4-IN-20 Chemical Structure

IRAK4-IN-20 Chemical Structure

CAS No. : 1931994-80-7

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Based on 1 publication(s) in Google Scholar

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Description

IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research[1].

IC50 & Target

IRAK4

3.55 nM (IC50)

In Vitro

IRAK4-IN-20 (Compound BAY-1834845) (500 nM, 20 h) decreases inflammatory cytokines secretion effectively in an in vitro treatment of LPS stimulated human peripheral blood mononuclear cells (PBMC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-20 Related Antibodies
In Vivo

IRAK4-IN-20 (Compound BAY-1834845) (150 mg/kg; p.o.; once or twice) effectively prevents acute respiratory distress syndrome in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice (aged 6–7 weeks), LPS-induced ARDS mouse model[1]
Dosage: 150 mg/kg
Administration: Oral administration, 30 min before LPS modeling or twice 4 h and 12 h after LPS modeling
Result: Remarkably decreased inflammatory cells infiltrating lung tissue and neutrophil count in BALF.
Effectively reduced the numbers of total T cells, monocyte, and macrophages.
Largely preserved the signatures of naïve lymphocytes and stromal cells such as endothelial cells, chondrocytes, and smooth muscle cells.
Regulated inflammation and innate immunity genes more efficiently than Dexamethasone (HY-14648).
Molecular Weight

450.45

Formula

C22H25F3N4O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=NC(C(F)(F)F)=CC=C1)NC2=CC3=CN(CCC(C)(O)C)N=C3C=C2C(C)(O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (277.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2200 mL 11.1000 mL 22.2000 mL
5 mM 0.4440 mL 2.2200 mL 4.4400 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2200 mL 11.1000 mL 22.2000 mL 55.5001 mL
5 mM 0.4440 mL 2.2200 mL 4.4400 mL 11.1000 mL
10 mM 0.2220 mL 1.1100 mL 2.2200 mL 5.5500 mL
15 mM 0.1480 mL 0.7400 mL 1.4800 mL 3.7000 mL
20 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL
25 mM 0.0888 mL 0.4440 mL 0.8880 mL 2.2200 mL
30 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8500 mL
40 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
50 mM 0.0444 mL 0.2220 mL 0.4440 mL 1.1100 mL
60 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
80 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.6938 mL
100 mM 0.0222 mL 0.1110 mL 0.2220 mL 0.5550 mL
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IRAK4-IN-20 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-201931994-80-7IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseacute respiratory distress syndromeARDSInhibitorinhibitorinhibit

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