2. Neuronal Signaling Anti-infection
  3. Cholinesterase (ChE) Parasite
  4. Isogarcinol

Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani.

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Isogarcinol Chemical Structure

Isogarcinol Chemical Structure

CAS No. : 71117-97-0

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Based on 1 publication(s) in Google Scholar

Isogarcinol Related Antibodies

Top Publications Citing Use of Products

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AChE BChE

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani[1].

IC50 & Target

AChE

1.13 ± 0.0 μM (IC50)

BChE

8.30 ± 0.0 μM (IC50)

Leishmania

0.33 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
19.21 μM
Compound: 1
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30500683]
HEL IC50
9.24 μM
Compound: 1
Antiproliferative activity against HEL cells after 72 hrs by MTT assay
Antiproliferative activity against HEL cells after 72 hrs by MTT assay
[PMID: 30500683]
HeLa IC50
16.46 μM
Compound: 1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 30500683]
HepG2 IC50
7.3 μM
Compound: 9
Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
[PMID: 24960143]
K562 IC50
14.1 μM
Compound: 1
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30500683]
L02 IC50
9.3 μM
Compound: 9
Cytotoxicity against human HL7702 cells by MTT assay
Cytotoxicity against human HL7702 cells by MTT assay
[PMID: 24960143]
MCF7 IC50
10.24 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30500683]
MCF7 IC50
4.8 μM
Compound: 9
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 24960143]
MDA-MB-231 IC50
5.7 μM
Compound: 9
Cytotoxicity against human MDA-MB-231 cells by MTT assay
Cytotoxicity against human MDA-MB-231 cells by MTT assay
[PMID: 24960143]
U-251 IC50
2.8 μM
Compound: 8
Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay
Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay
[PMID: 28729053]
Molecular Weight

602.80

Formula

C38H50O6
CAS No.
SMILES

O=C1[C@@]23C(OC(C)([C@H](C3)C/C=C(C)\C)C)=C(C([C@@]1(C(C)([C@@H](C2)C/C=C(C)\C)C)C/C=C(C)\C)=O)C(C4=CC(O)=C(C=C4)O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Isogarcinol Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isogarcinol71117-97-0CamboginCholinesterase (ChE)ParasiteInhibitorinhibitorinhibit

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