Isonipecotic acid

Cat. No.: HY-Y1176 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Isonipecotic acid is a GABAA receptor partial agonist.

For research use only. We do not sell to patients.

Isonipecotic acid Chemical Structure

CAS No. : 498-94-2

Size	Price	Stock	Quantity
10 g	USD 25	In-stock	Estimated Time of Arrival: December 31
25 g	USD 50	In-stock	Estimated Time of Arrival: December 31
50 g	USD 70	In-stock	Estimated Time of Arrival: December 31
> 100 g		Get quote

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Other Forms of Isonipecotic acid:

Isonipecotic acid-d₉ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Isonipecotic acid is a GABAA receptor partial agonist^[1].

IC₅₀ & Target

GABAA Receptor^[1]

In Vitro

Isonipecotic acid inhibits [³H]GABA binding (2°C) with an IC₅₀ of 0.33 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

129.16

Formula

C₆H₁₁NO₂

CAS No.

498-94-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1CCNCC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (774.23 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.7423 mL	38.7117 mL	77.4233 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (245 KB) HNMR (229 KB)

Handling Instructions (2659 KB)

References

[1]. Krehan D, et al. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int. 2003 Jun;42(7):561-5. [Content Brief]

[2]. Falch E, et al. GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid. J Neurochem. 1985 Jan;44(1):68-75. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.7423 mL	38.7117 mL	77.4233 mL	193.5584 mL
	5 mM	1.5485 mL	7.7423 mL	15.4847 mL	38.7117 mL
	10 mM	0.7742 mL	3.8712 mL	7.7423 mL	19.3558 mL
	15 mM	0.5162 mL	2.5808 mL	5.1616 mL	12.9039 mL
	20 mM	0.3871 mL	1.9356 mL	3.8712 mL	9.6779 mL
	25 mM	0.3097 mL	1.5485 mL	3.0969 mL	7.7423 mL
	30 mM	0.2581 mL	1.2904 mL	2.5808 mL	6.4519 mL
	40 mM	0.1936 mL	0.9678 mL	1.9356 mL	4.8390 mL
	50 mM	0.1548 mL	0.7742 mL	1.5485 mL	3.8712 mL
	60 mM	0.1290 mL	0.6452 mL	1.2904 mL	3.2260 mL
	80 mM	0.0968 mL	0.4839 mL	0.9678 mL	2.4195 mL
	100 mM	0.0774 mL	0.3871 mL	0.7742 mL	1.9356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.