Isoxsuprine

Cat. No.: HY-B1270A: FAQs
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Isoxsuprine is a beta-adrenergic receptor agonist with K_is of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

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Isoxsuprine Chemical Structure

CAS No. : 395-28-8

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Other In-stock Forms of Isoxsuprine:

Isoxsuprine hydrochloride

Other Forms of Isoxsuprine:

Isoxsuprine hydrochloride In-stock

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description	Isoxsuprine is a beta-adrenergic receptor agonist with K_is of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
IC₅₀ & Target	Ki: 13.65 μΜ (myometrial beta-adrenergic receptor), 3.48 μΜ (placcntal beta-adrenergic receptor)^[1] NMDA receptor^[3]
In Vitro	Results show that Isoxsuprine inhibits CCID formation dose dependently (5 to 60 μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin)^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Isoxsuprine Related Antibodies
In Vivo	Total infarct volume in vehicle-treated animals is 279±25 mm³ compare to 137±18 mm³ in Isoxsuprine -treated animals^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	301.38
Formula	C₁₈H₂₃NO₃
CAS No.	395-28-8
SMILES	OC1=CC=C(C(C(C)NC(COC2=CC=CC=C2)C)O)C=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Falkay G, et al. Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors. J Perinat Med. 1986;14(2):109-13. [Content Brief] [2]. Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8. [Content Brief] [3]. Hill JW, et al. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9(5):e96761. [Content Brief]

Cell Assay ^[2]	MCF-7^ALOX12 cells are seeded in 3.5-cm dishes and grown in 2.5 mL complete MEM medium without selection pressure. The next day, the medium is changed to serum-free medium and cells are kept at 37 °C for 24 h. Then, cells are treated with 10 μM arachidonic acid and simultaneously with different concentrations of Isoxsuprine for 4 h when the supernatants are aspirated, centrifuged at 2000, r.p.m. at 4 °C for 5 min, collected in cryo-tubes, flash frozen and stored at -80 °C until analysis^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[3]	Male spontaneously hypertensive rats (SHR) weighing 290 to 300 g are used in this study. At reperfusion, animals receive 0.5 mL of vehicle (0.6% DMSO in normal saline) or 1 mg/kg Isoxsuprine by intravenous (IV) injection through the lateral tail vein. All animals receive 3 mL of subcutaneous saline after surgery to prevent dehydration. After 24 hours reperfusion, animals are sacrificed, brains are sectioned into 4 mm-thick quadrants, and infarcted tissue is identified by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Edema-corrected infarct volume is calculated by subtracting the area of non-infarcted tissue in the ipsilateral hemisphere from the total volume of the contralateral hemisphere. Infarct volume is quantified using Image J software^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Falkay G, et al. Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors. J Perinat Med. 1986;14(2):109-13. [Content Brief] [2]. Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8. [Content Brief] [3]. Hill JW, et al. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9(5):e96761. [Content Brief]

Isoxsuprine Related Classifications

Neurological Disease Endocrinology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoxsuprine395-28-8Adrenergic ReceptoriGluRBeta ReceptorIonotropic glutamate receptorsInhibitorinhibitorinhibit

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