2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. ITH12575

ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations.

For research use only. We do not sell to patients.

ITH12575 Chemical Structure

ITH12575 Chemical Structure

CAS No. : 1802013-08-6

Size Price Stock Quantity
5 mg USD 95 In-stock
10 mg USD 155 In-stock
25 mg USD 310 In-stock
50 mg USD 500 In-stock
100 mg USD 800 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

ITH12575 Related Antibodies

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View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

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Description

ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].

Molecular Weight

331.86

Formula

C18H18ClNOS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3C(C)C)SC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (150.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0133 mL 15.0666 mL 30.1332 mL
5 mM 0.6027 mL 3.0133 mL 6.0266 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.53 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0133 mL 15.0666 mL 30.1332 mL 75.3330 mL
5 mM 0.6027 mL 3.0133 mL 6.0266 mL 15.0666 mL
10 mM 0.3013 mL 1.5067 mL 3.0133 mL 7.5333 mL
15 mM 0.2009 mL 1.0044 mL 2.0089 mL 5.0222 mL
20 mM 0.1507 mL 0.7533 mL 1.5067 mL 3.7666 mL
25 mM 0.1205 mL 0.6027 mL 1.2053 mL 3.0133 mL
30 mM 0.1004 mL 0.5022 mL 1.0044 mL 2.5111 mL
40 mM 0.0753 mL 0.3767 mL 0.7533 mL 1.8833 mL
50 mM 0.0603 mL 0.3013 mL 0.6027 mL 1.5067 mL
60 mM 0.0502 mL 0.2511 mL 0.5022 mL 1.2555 mL
80 mM 0.0377 mL 0.1883 mL 0.3767 mL 0.9417 mL
100 mM 0.0301 mL 0.1507 mL 0.3013 mL 0.7533 mL
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ITH12575 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITH125751802013-08-6ITH 12575ITH-12575Calcium ChannelCa2+ channelsCa channelsmNCXCALHM1antihistaminicneuroprotectantInhibitorinhibitorinhibit

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