2. Anti-infection
  3. Parasite SARS-CoV
  4. Ivermectin B1b

Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture.

For research use only. We do not sell to patients.

Ivermectin B1b Chemical Structure

Ivermectin B1b Chemical Structure

CAS No. : 70209-81-3

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500 μg USD 730 In-stock

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Based on 1 publication(s) in Google Scholar

Ivermectin B1b Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].

In Vitro

Ivermectin and Ivermectin B1b are the most potent inhibitors of contraction and motility in both susceptible isolates (H. contortus McMaster and and O. circumcincta McMaster) also show the highest resistance ratios in both species[3].
Vermectin is a macrocyclic lactone that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs) but has no modulatory activity on 5-HT3 receptors[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ivermectin B1b Related Antibodies
In Vivo

Ivermectin B1b causes snail death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

861.07

Formula

C47H72O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC([C@H]1O[C@]2(CC[C@@H]1C)C[C@](O3)([H])C[C@](C/C=C([C@H]([C@H](/C=C/C=C4[C@@]5(O)[C@](C=C(C)[C@@H](O)[C@@]5([H])OC/4)([H])C3=O)C)O[C@@]6([H])C[C@@H]([C@@H](O[C@@]7([H])C[C@@H]([C@@H](O)[C@H](C)O7)OC)[C@H](C)O6)OC)\C)([H])O2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (58.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1613 mL 5.8067 mL 11.6135 mL
5 mM 0.2323 mL 1.1613 mL 2.3227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1613 mL 5.8067 mL 11.6135 mL 29.0336 mL
5 mM 0.2323 mL 1.1613 mL 2.3227 mL 5.8067 mL
10 mM 0.1161 mL 0.5807 mL 1.1613 mL 2.9034 mL
15 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9356 mL
20 mM 0.0581 mL 0.2903 mL 0.5807 mL 1.4517 mL
25 mM 0.0465 mL 0.2323 mL 0.4645 mL 1.1613 mL
30 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.9678 mL
40 mM 0.0290 mL 0.1452 mL 0.2903 mL 0.7258 mL
50 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.5807 mL
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Ivermectin B1b Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ivermectin B1b70209-81-3ParasiteSARS-CoVSARS coronaviruscontractionmotilityantiparasiticneuronsmusclecellsSARS-CoV-2COVID-19Inhibitorinhibitorinhibit

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