2. Epigenetics
  3. Histone Acetyltransferase
  4. JG-2016

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC50 of 14.8 μM in the HAT1 acetylation assays.

For research use only. We do not sell to patients.

JG-2016 Chemical Structure

JG-2016 Chemical Structure

CAS No. : 2887480-87-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 396 In-stock
Solution
10 mM * 1 mL in DMSO USD 396 In-stock
Solid
1 mg USD 144 In-stock
5 mg USD 360 In-stock
10 mg USD 580 In-stock
25 mg USD 1150 In-stock
50 mg USD 1850 In-stock
100 mg USD 3000 In-stock
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JG-2016 Related Antibodies

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Description

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC50 of 14.8 μM in the HAT1 acetylation assays[1].

Molecular Weight

376.84

Formula

C18H21ClN4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)N=C2N(CCOCC(C)C)C3=CC(CC)=C(Cl)C=C3N=C2C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (265.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6536 mL 13.2682 mL 26.5365 mL
5 mM 0.5307 mL 2.6536 mL 5.3073 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.00%

COA (253 KB) HNMR (137 KB) RP-HPLC (139 KB) LCMS (356 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6536 mL 13.2682 mL 26.5365 mL 66.3412 mL
5 mM 0.5307 mL 2.6536 mL 5.3073 mL 13.2682 mL
10 mM 0.2654 mL 1.3268 mL 2.6536 mL 6.6341 mL
15 mM 0.1769 mL 0.8845 mL 1.7691 mL 4.4227 mL
20 mM 0.1327 mL 0.6634 mL 1.3268 mL 3.3171 mL
25 mM 0.1061 mL 0.5307 mL 1.0615 mL 2.6536 mL
30 mM 0.0885 mL 0.4423 mL 0.8845 mL 2.2114 mL
40 mM 0.0663 mL 0.3317 mL 0.6634 mL 1.6585 mL
50 mM 0.0531 mL 0.2654 mL 0.5307 mL 1.3268 mL
60 mM 0.0442 mL 0.2211 mL 0.4423 mL 1.1057 mL
80 mM 0.0332 mL 0.1659 mL 0.3317 mL 0.8293 mL
100 mM 0.0265 mL 0.1327 mL 0.2654 mL 0.6634 mL
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JG-2016 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JG-20162887480-87-5JG2016JG 2016Histone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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