JG-2016

Cat. No.: HY-154944 Purity: 99.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC₅₀ of 14.8 μM in the HAT1 acetylation assays.

For research use only. We do not sell to patients.

JG-2016 Chemical Structure

CAS No. : 2887480-87-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 396	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 396	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 144	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC₅₀ of 14.8 μM in the HAT1 acetylation assays^[1].

Molecular Weight

376.84

Formula

C₁₈H₂₁ClN₄O₃

CAS No.

2887480-87-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)N=C2N(CCOCC(C)C)C3=CC(CC)=C(Cl)C=C3N=C2C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (265.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6536 mL	13.2682 mL	26.5365 mL
5 mM	0.5307 mL	2.6536 mL	5.3073 mL
10 mM	0.2654 mL	1.3268 mL	2.6536 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.00%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (253 KB) HNMR (137 KB) RP-HPLC (139 KB) LCMS (356 KB)

Handling Instructions (2659 KB)

References

[1]. Joshua James GRUBER, et al. Modulators of histone acetyltransferase 1 and methods of treatment thereof. Patent, WO2022272313A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6536 mL	13.2682 mL	26.5365 mL	66.3412 mL
	5 mM	0.5307 mL	2.6536 mL	5.3073 mL	13.2682 mL
	10 mM	0.2654 mL	1.3268 mL	2.6536 mL	6.6341 mL
	15 mM	0.1769 mL	0.8845 mL	1.7691 mL	4.4227 mL
	20 mM	0.1327 mL	0.6634 mL	1.3268 mL	3.3171 mL
	25 mM	0.1061 mL	0.5307 mL	1.0615 mL	2.6536 mL
	30 mM	0.0885 mL	0.4423 mL	0.8845 mL	2.2114 mL
	40 mM	0.0663 mL	0.3317 mL	0.6634 mL	1.6585 mL
	50 mM	0.0531 mL	0.2654 mL	0.5307 mL	1.3268 mL
	60 mM	0.0442 mL	0.2211 mL	0.4423 mL	1.1057 mL
	80 mM	0.0332 mL	0.1659 mL	0.3317 mL	0.8293 mL
	100 mM	0.0265 mL	0.1327 mL	0.2654 mL	0.6634 mL

JG-2016 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JG-20162887480-87-5JG2016JG 2016Histone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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