2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. JH-RE-06-d6

JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Ki=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.

For research use only. We do not sell to patients.

JH-RE-06-d<sub>6</sub> Chemical Structure

JH-RE-06-d6 Chemical Structure

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1 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
5 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
10 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
50 mg   Get quote  
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JH-RE-06-d6 Related Antibodies

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Description

JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Ki=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[1].

Molecular Weight

474.75

Formula

C20H10D6Cl3N3O4
Unlabeled CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C(CC(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C(NC2=C(Cl)C=C(Cl)C=C2)NC3=C1C([N+]([O-])=O)=CC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1064 mL 10.5319 mL 21.0637 mL
5 mM 0.4213 mL 2.1064 mL 4.2127 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1064 mL 10.5319 mL 21.0637 mL 52.6593 mL
5 mM 0.4213 mL 2.1064 mL 4.2127 mL 10.5319 mL
10 mM 0.2106 mL 1.0532 mL 2.1064 mL 5.2659 mL
15 mM 0.1404 mL 0.7021 mL 1.4042 mL 3.5106 mL
20 mM 0.1053 mL 0.5266 mL 1.0532 mL 2.6330 mL
25 mM 0.0843 mL 0.4213 mL 0.8425 mL 2.1064 mL
30 mM 0.0702 mL 0.3511 mL 0.7021 mL 1.7553 mL
40 mM 0.0527 mL 0.2633 mL 0.5266 mL 1.3165 mL
50 mM 0.0421 mL 0.2106 mL 0.4213 mL 1.0532 mL
60 mM 0.0351 mL 0.1755 mL 0.3511 mL 0.8777 mL
80 mM 0.0263 mL 0.1316 mL 0.2633 mL 0.6582 mL
100 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5266 mL
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JH-RE-06-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JH-RE-06-d6DNA/RNA SynthesisRev1+/+ MEF cellsA375 xenograft tumorInhibitorinhibitorinhibit

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