2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. JH-RE-06

JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.

For research use only. We do not sell to patients.

JH-RE-06 Chemical Structure

JH-RE-06 Chemical Structure

CAS No. : 1361227-90-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of JH-RE-06:

JH-RE-06 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[1][2].

IC50 & Target

IC50: 0.78 μM (REV1-REV7)[1]
Kd: 0.42 μM (REV1-REV7)[1]
In Vitro

JH-RE-06 unexpectedly induces dimerization of the REV1 CTD at its REV7-binding surface and blocks the REV1-REV7 interaction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JH-RE-06 Related Antibodies
In Vivo

JH-RE-06 inhibits mutagenic TLS and enhances cisplatin-induced toxicity in cultured human and mouse cell lines[1].
Co-administration of JH-RE-06 with cisplatin suppresses the growth of xenograft human melanomas in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

468.72

Formula

C20H16Cl3N3O4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1C(C(CC(C)C)=O)=C(NC2=C(Cl)C=C(Cl)C=C2)NC3=C1C([N+]([O-])=O)=CC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (213.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1335 mL 10.6673 mL 21.3347 mL
5 mM 0.4267 mL 2.1335 mL 4.2669 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

SDS (393 KB)

COA (255 KB) HNMR (259 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1335 mL 10.6673 mL 21.3347 mL 53.3367 mL
5 mM 0.4267 mL 2.1335 mL 4.2669 mL 10.6673 mL
10 mM 0.2133 mL 1.0667 mL 2.1335 mL 5.3337 mL
15 mM 0.1422 mL 0.7112 mL 1.4223 mL 3.5558 mL
20 mM 0.1067 mL 0.5334 mL 1.0667 mL 2.6668 mL
25 mM 0.0853 mL 0.4267 mL 0.8534 mL 2.1335 mL
30 mM 0.0711 mL 0.3556 mL 0.7112 mL 1.7779 mL
40 mM 0.0533 mL 0.2667 mL 0.5334 mL 1.3334 mL
50 mM 0.0427 mL 0.2133 mL 0.4267 mL 1.0667 mL
60 mM 0.0356 mL 0.1778 mL 0.3556 mL 0.8889 mL
80 mM 0.0267 mL 0.1333 mL 0.2667 mL 0.6667 mL
100 mM 0.0213 mL 0.1067 mL 0.2133 mL 0.5334 mL
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JH-RE-06 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JH-RE-061361227-90-8DNA/RNA SynthesisInhibitorinhibitorinhibit

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