2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. JMV 449 acetate

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.

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Custom Peptide Synthesis

JMV 449 acetate Chemical Structure

JMV 449 acetate Chemical Structure

CAS No. : 141863-45-8

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5 mg USD 560 In-stock
10 mg USD 900 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

In Vivo

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice[1]
Dosage: 120 pmol/mouse
Administration: I.c.v.
Result: Showed dose-response relation-ships for the analgesic effect.
Molecular Weight

807.03

Formula

C40H70N8O9
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (123.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2391 mL 6.1956 mL 12.3911 mL
5 mM 0.2478 mL 1.2391 mL 2.4782 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.84%

COA (258 KB) RP-HPLC (111 KB) MS (78 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2391 mL 6.1956 mL 12.3911 mL 30.9778 mL
5 mM 0.2478 mL 1.2391 mL 2.4782 mL 6.1956 mL
10 mM 0.1239 mL 0.6196 mL 1.2391 mL 3.0978 mL
15 mM 0.0826 mL 0.4130 mL 0.8261 mL 2.0652 mL
20 mM 0.0620 mL 0.3098 mL 0.6196 mL 1.5489 mL
25 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2391 mL
30 mM 0.0413 mL 0.2065 mL 0.4130 mL 1.0326 mL
40 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7744 mL
50 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6196 mL
60 mM 0.0207 mL 0.1033 mL 0.2065 mL 0.5163 mL
80 mM 0.0155 mL 0.0774 mL 0.1549 mL 0.3872 mL
100 mM 0.0124 mL 0.0620 mL 0.1239 mL 0.3098 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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JMV 449 acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMV 449141863-45-8JMV449JMV-449Neurotensin Receptorpseudopeptideanalogueneurotensin8-13hypothermicneuroprotectiveInhibitorinhibitorinhibit

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