2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. JMV 449

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse.

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JMV 449 Chemical Structure

JMV 449 Chemical Structure

CAS No. : 139026-66-7

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Description

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

In Vivo

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice[2]
Dosage: 120 pmol/mouse
Administration: i.c.v.
Result: Showed dose-response relation-ships for the analgesic effect.
Molecular Weight

746.98

Formula

C38H66N8O7
CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JMV 449 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMV 449139026-66-7JMV449JMV-449Neurotensin Receptorpseudopeptideanalogueneurotensin8-13hypothermicneuroprotectiveInhibitorinhibitorinhibit

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