JNJ-10311795  (Synonyms: RWJ-355871)

JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (K_i = 38 nM) and mast cell chymase (K_i = 2.3 nM), exhibits noteworthy antiinflammatory activity^[1].

Ki: 38 nM (cathepsin G), 2.3 nM (chymase)^[1].

670.69

C₄₀H₃₅N₂O₆P

518062-14-1

OP(O)(C(C1=C2C=CC=CC2=CC=C1)C(C3=C(C(N(C)C4CCN(C(C5=CC=C6C=CC=CC6=C5)=O)CC4)=O)C=C7C=CC=CC7=C3)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lawrence de Garavilla, et al. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem. 2005 May 6;280(18):18001-7.  [Content Brief]