2. Cell Cycle/DNA Damage
  3. CDK
  4. JSH-009 dimaleate

JSH-009 dimaleate (Compound 1) is a potent and highly selective CDK9 inhibitor with an IC50 of 0.928 nM. JSH-009 can effectively inhibit the growth of subcutaneous tumor (cute myelogenous leukemia MV4-11) mice.

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JSH-009 dimaleate Chemical Structure

JSH-009 dimaleate Chemical Structure

CAS No. : 2559759-04-3

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Other Forms of JSH-009 dimaleate:

JSH-009 dimaleate Related Antibodies

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Description

JSH-009 dimaleate (Compound 1) is a potent and highly selective CDK9 inhibitor with an IC50 of 0.928 nM. JSH-009 can effectively inhibit the growth of subcutaneous tumor (cute myelogenous leukemia MV4-11) mice[1].

IC50 & Target[1]

CDK9/cyclinT1

0.928 nM (IC50)

CDK1/cyclinB

5410 nM (IC50)

CDK2/cyclinA

6850 nM (IC50)

CDK3/cyclin E1

>10,000 nM (IC50)

Cdk5/p25

6950 nM (IC50)

CDK7/Cyclin H/MNAT1

3700 nM (IC50)

CDK8/cyclin C

>10,000 nM (IC50)

CDK11

>10,000 nM (IC50)

CDK14/Cyclin Y

2710 nM (IC50)

CDK16/Cyclin Y

195 nM (IC50)

Molecular Weight

751.25

Formula

C33H43ClN6O10S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC[C@@H](C)N[C@@H](CC1)CC[C@H]1NC2=CC(C3=CSC(NCC4(CCOCC4)C#N)=N3)=C(Cl)C=N2.OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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JSH-009 dimaleate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JSH-009 dimaleate2559759-04-3CDKCyclin dependent kinaseCDK9myelogenous leukemiaMV4-11Inhibitorinhibitorinhibit

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