2. Cell Cycle/DNA Damage
  3. CDK
  4. JSH-009

JSH-009 is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation. JSH-009 demonstrated significant in vitro and in vivo efficacy against acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

JSH-009 Chemical Structure

JSH-009 Chemical Structure

CAS No. : 2247481-08-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of JSH-009:

JSH-009 Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

JSH-009 is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation. JSH-009 demonstrated significant in vitro and in vivo efficacy against acute myeloid leukemia (AML)[1].

IC50 & Target

CDK9

 

Cellular Effect
Cell Line Type Value Description References
MV4-11 GI50
0.014 μM
Compound: 41
Antiproliferative activity against human MV4-11 cells after 72 hrs by Celltiter-Glo assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by Celltiter-Glo assay
[PMID: 30253346]
Molecular Weight

519.10

Formula

C25H35ClN6O2S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

COC[C@@H](C)N[C@@H](CC1)CC[C@H]1NC2=CC(C3=CSC(NCC4(CCOCC4)C#N)=N3)=C(Cl)C=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (192.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9264 mL 9.6321 mL 19.2641 mL
5 mM 0.3853 mL 1.9264 mL 3.8528 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.21%

SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9264 mL 9.6321 mL 19.2641 mL 48.1603 mL
5 mM 0.3853 mL 1.9264 mL 3.8528 mL 9.6321 mL
10 mM 0.1926 mL 0.9632 mL 1.9264 mL 4.8160 mL
15 mM 0.1284 mL 0.6421 mL 1.2843 mL 3.2107 mL
20 mM 0.0963 mL 0.4816 mL 0.9632 mL 2.4080 mL
25 mM 0.0771 mL 0.3853 mL 0.7706 mL 1.9264 mL
30 mM 0.0642 mL 0.3211 mL 0.6421 mL 1.6053 mL
40 mM 0.0482 mL 0.2408 mL 0.4816 mL 1.2040 mL
50 mM 0.0385 mL 0.1926 mL 0.3853 mL 0.9632 mL
60 mM 0.0321 mL 0.1605 mL 0.3211 mL 0.8027 mL
80 mM 0.0241 mL 0.1204 mL 0.2408 mL 0.6020 mL
100 mM 0.0193 mL 0.0963 mL 0.1926 mL 0.4816 mL
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JSH-009 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JSH-0092247481-08-7JSH009JSH 009CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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