2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. JW-65

JW-65 (compound 20) is a TRPC3 inhibitor. JW-65 can be used in neurological and cardiovascular disease related research.

For research use only. We do not sell to patients.

JW-65 Chemical Structure

JW-65 Chemical Structure

CAS No. : 2763378-71-6

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Based on 1 publication(s) in Google Scholar

JW-65 Related Antibodies

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Description

JW-65 (compound 20) is a TRPC3 inhibitor. JW-65 can be used in neurological and cardiovascular disease related research[1].

IC50 & Target

TRPC3

 

Molecular Weight

445.22

Formula

C18H13Cl2F3N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=C(C(NCC)=O)C=NN1C2=CC=C(C=C2)N(C=CC(Cl)=C3Cl)C3=O)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (56.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2461 mL 11.2304 mL 22.4608 mL
5 mM 0.4492 mL 2.2461 mL 4.4922 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2461 mL 11.2304 mL 22.4608 mL 56.1520 mL
5 mM 0.4492 mL 2.2461 mL 4.4922 mL 11.2304 mL
10 mM 0.2246 mL 1.1230 mL 2.2461 mL 5.6152 mL
15 mM 0.1497 mL 0.7487 mL 1.4974 mL 3.7435 mL
20 mM 0.1123 mL 0.5615 mL 1.1230 mL 2.8076 mL
25 mM 0.0898 mL 0.4492 mL 0.8984 mL 2.2461 mL
30 mM 0.0749 mL 0.3743 mL 0.7487 mL 1.8717 mL
40 mM 0.0562 mL 0.2808 mL 0.5615 mL 1.4038 mL
50 mM 0.0449 mL 0.2246 mL 0.4492 mL 1.1230 mL
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JW-65 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JW-652763378-71-6JW65JW 65TRP ChannelTransient receptor potential channelscalcium channelspentylenetetrazolepilocarpineseizurestatus epilepticustransient receptor potential channelsInhibitorinhibitorinhibit

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