2. PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  3. PI3K Akt GSK-3 Apoptosis
  4. JZ19

JZ19 reduces the LDH and ROS levels, and exhibits antioxidant activity against oxygen-glucose deprivation (OGD)-induced cardiomyocyte injury. JZ19 reverses Isoproterenol (HY-B0468)-induced cardiomyocyte hypertrophy and apoptosis through PI3K-AKT-GSK3β signaling pathway. JZ19 alleviates Isoproterenol (HY-B0468)-induced heart failure in mouse models.

For research use only. We do not sell to patients.

JZ19 Chemical Structure

JZ19 Chemical Structure

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JZ19 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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GSK-3 GSK-3α GSK-3β

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Description

JZ19 reduces the LDH and ROS levels, and exhibits antioxidant activity against oxygen-glucose deprivation (OGD)-induced cardiomyocyte injury. JZ19 reverses Isoproterenol (HY-B0468)-induced cardiomyocyte hypertrophy and apoptosis through PI3K-AKT-GSK3β signaling pathway. JZ19 alleviates Isoproterenol (HY-B0468)-induced heart failure in mouse models[1].

Molecular Weight

506.42

Formula

C22H25F3O10
SMILES

[H][C@@]1([C@@]2([C@@H](OC=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)[H])[C@@H]([C@H]4[C@@]2(O4)COC5=CC=C(C=C5)C(F)(F)F)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JZ19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JZ19JZ 19JZ-19PI3KAktGSK-3ApoptosisPhosphoinositide 3-kinasePKBProtein kinase BGlycogen synthase kinase-3Glycogen synthase kinase 3H9c2heart failurehypertrophyC57/6J mouseInhibitorinhibitorinhibit

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