2. GPCR/G Protein NF-κB MAPK/ERK Pathway
  3. Protease Activated Receptor (PAR) NF-κB p38 MAPK
  4. K-14585

K-14585 is a peptide competitive PAR2 antagonist. K-14585 inhibits PAR2-dependent IL-8 production, NF-κB phosphorylation, and p38 signaling. K-14585 reduces SLIGKV (PAR2 agonist peptide)-induced Ca2+ mobilisation in primary human keratinocytes.

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K-14585 Chemical Structure

K-14585 Chemical Structure

CAS No. : 880546-17-8

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K-14585 Related Antibodies

Top Publications Citing Use of Products

View All Protease Activated Receptor (PAR) Isoform Specific Products:

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PAR1 PAR2 PAR4

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

K-14585 is a peptide competitive PAR2 antagonist. K-14585 inhibits PAR2-dependent IL-8 production, NF-κB phosphorylation, and p38 signaling. K-14585 reduces SLIGKV (PAR2 agonist peptide)-induced Ca2+ mobilisation in primary human keratinocytes[1][2][3].

IC50 & Target

PAR2

 

Molecular Weight

915.95

Formula

C51H56Cl2N8O4
CAS No.
SMILES

ClC(C=CC=C1Cl)=C1CN2C(C(C(CN3CCCC3)=C2)=C4)=CC=C4NC(NCC(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=CC=C5)C(NC(C6=CC=CC=C6)C7=CC=CC=C7)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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K-14585 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-14585880546-17-8K14585K 14585Protease Activated Receptor (PAR)NF-κBp38 MAPKThrombin receptorsNuclear factor-κBNuclear factor-kappaBPAR2 signalInhibitorinhibitorinhibit

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