2. Cytoskeleton Apoptosis
  3. Integrin Apoptosis
  4. K34c

K34c is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c can be used in glioblastoma research.

For research use only. We do not sell to patients.

K34c Chemical Structure

K34c Chemical Structure

CAS No. : 939769-93-4

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Based on 1 publication(s) in Google Scholar

K34c Related Antibodies

Top Publications Citing Use of Products

View All Integrin Isoform Specific Products:

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

K34c is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c can be used in glioblastoma research[1].

IC50 & Target[1]

α5β1

 

In Vitro

K34c (20 μM; 24 or 48 h) significantly induces U87MG cells apoptosis in combination with 1 μM Ellipticine (HY-15753)[1].
K34c (20 μM; 48 h) significantly decreases Temozolomide (HY-17364)-induced senescence in cells transfected with control non targeting siRNA without affecting significantly the residual senescence of cells transfected with siRNA specific for p53[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K34c Related Antibodies

Apoptosis Analysis[1]

Cell Line: U87MG cells
Concentration: 20 μM
Incubation Time: 24 or 48 h
Result: Induced apoptosis, led to a significant increase in apoptotic cell death measured by the population of sub-G1 cells in combination with 1 μM Ellipticine (HY-15753).

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Decreased Ellipticine (HY-15753)- and Temozolomide (HY-17364)-induced activation of p53.
Molecular Weight

447.53

Formula

C26H29N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CC1=CC=C(OCCCNC2=NC=CC=C2)C=C1)NC(C3=C(C)C=CC=C3C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (279.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2345 mL 11.1724 mL 22.3449 mL
5 mM 0.4469 mL 2.2345 mL 4.4690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2345 mL 11.1724 mL 22.3449 mL 55.8622 mL
5 mM 0.4469 mL 2.2345 mL 4.4690 mL 11.1724 mL
10 mM 0.2234 mL 1.1172 mL 2.2345 mL 5.5862 mL
15 mM 0.1490 mL 0.7448 mL 1.4897 mL 3.7241 mL
20 mM 0.1117 mL 0.5586 mL 1.1172 mL 2.7931 mL
25 mM 0.0894 mL 0.4469 mL 0.8938 mL 2.2345 mL
30 mM 0.0745 mL 0.3724 mL 0.7448 mL 1.8621 mL
40 mM 0.0559 mL 0.2793 mL 0.5586 mL 1.3966 mL
50 mM 0.0447 mL 0.2234 mL 0.4469 mL 1.1172 mL
60 mM 0.0372 mL 0.1862 mL 0.3724 mL 0.9310 mL
80 mM 0.0279 mL 0.1397 mL 0.2793 mL 0.6983 mL
100 mM 0.0223 mL 0.1117 mL 0.2234 mL 0.5586 mL
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K34c Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K34c939769-93-4IntegrinApoptosisU87MGglioblastomaα5β1 integrinInhibitorinhibitorinhibit

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