2. Apoptosis Stem Cell/Wnt
  3. Apoptosis YAP
  4. KHKI-01215

KHKI-01215 is an inhibitor for NUAK2 with an IC50 of 0.052 μM. KHKI-01215 inhibits the proliferation of cancer cell SW480 with an IC50 of 3.16 μM, induces apoptosis in SW480. KHKI-01215 inhibits the YAP signaling pathway.

For research use only. We do not sell to patients.

KHKI-01215 Chemical Structure

KHKI-01215 Chemical Structure

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

KHKI-01215 Related Antibodies

Top Publications Citing Use of Products

View All YAP Isoform Specific Products:

View All Isoforms
YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KHKI-01215 is an inhibitor for NUAK2 with an IC50 of 0.052 μM. KHKI-01215 inhibits the proliferation of cancer cell SW480 with an IC50 of 3.16 μM, induces apoptosis in SW480. KHKI-01215 inhibits the YAP signaling pathway[1].

Molecular Weight

598.40

Formula

C24H26F3IN6O
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=CC(NC2=NC=C(I)C(OC3=CC=CC(N(C)C)=C3)=N2)=CC=C1N4CCN(C)CC4)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (208.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6711 mL 8.3556 mL 16.7112 mL
5 mM 0.3342 mL 1.6711 mL 3.3422 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6711 mL 8.3556 mL 16.7112 mL 41.7781 mL
5 mM 0.3342 mL 1.6711 mL 3.3422 mL 8.3556 mL
10 mM 0.1671 mL 0.8356 mL 1.6711 mL 4.1778 mL
15 mM 0.1114 mL 0.5570 mL 1.1141 mL 2.7852 mL
20 mM 0.0836 mL 0.4178 mL 0.8356 mL 2.0889 mL
25 mM 0.0668 mL 0.3342 mL 0.6684 mL 1.6711 mL
30 mM 0.0557 mL 0.2785 mL 0.5570 mL 1.3926 mL
40 mM 0.0418 mL 0.2089 mL 0.4178 mL 1.0445 mL
50 mM 0.0334 mL 0.1671 mL 0.3342 mL 0.8356 mL
60 mM 0.0279 mL 0.1393 mL 0.2785 mL 0.6963 mL
80 mM 0.0209 mL 0.1044 mL 0.2089 mL 0.5222 mL
100 mM 0.0167 mL 0.0836 mL 0.1671 mL 0.4178 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

KHKI-01215 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KHKI-01215KHKI01215KHKI 01215ApoptosisYAPYes-associated proteinSW480colorectal cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
KHKI-01215
Cat. No.:
HY-162709
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.