2. Anti-infection
  3. Dengue virus Flavivirus Influenza Virus HCV
  4. KIN101

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.

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KIN101 Chemical Structure

KIN101 Chemical Structure

CAS No. : 610753-87-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 90 In-stock
50 mg USD 260 In-stock
100 mg USD 390 In-stock
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

KIN101 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2].

IC50 & Target

IC50: 2 μM (influenza virus) and >5 μM (DNV)[1]
In Vitro

KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1].
KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels[1].
KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].
KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1].
KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].
KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIN101 Related Antibodies

Western Blot Analysis[1]

Cell Line: MRC5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Caused a significant decrease in the NP protein abundance.

RT-PCR[1]

Cell Line: Huh7 cells
Concentration: 10 μM
Incubation Time: 18 hours
Result: Showed a >1 log decrease in HCV RNA levels.
Molecular Weight

395.22

Formula

C16H11BrO5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C2=CC=C(Br)C=C2)=COC3=CC(OS(=O)(C)=O)=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (105.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5302 mL 12.6512 mL 25.3024 mL
5 mM 0.5060 mL 2.5302 mL 5.0605 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.26 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5302 mL 12.6512 mL 25.3024 mL 63.2559 mL
5 mM 0.5060 mL 2.5302 mL 5.0605 mL 12.6512 mL
10 mM 0.2530 mL 1.2651 mL 2.5302 mL 6.3256 mL
15 mM 0.1687 mL 0.8434 mL 1.6868 mL 4.2171 mL
20 mM 0.1265 mL 0.6326 mL 1.2651 mL 3.1628 mL
25 mM 0.1012 mL 0.5060 mL 1.0121 mL 2.5302 mL
30 mM 0.0843 mL 0.4217 mL 0.8434 mL 2.1085 mL
40 mM 0.0633 mL 0.3163 mL 0.6326 mL 1.5814 mL
50 mM 0.0506 mL 0.2530 mL 0.5060 mL 1.2651 mL
60 mM 0.0422 mL 0.2109 mL 0.4217 mL 1.0543 mL
80 mM 0.0316 mL 0.1581 mL 0.3163 mL 0.7907 mL
100 mM 0.0253 mL 0.1265 mL 0.2530 mL 0.6326 mL
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KIN101 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIN101610753-87-2KIN 101KIN-101Dengue virusFlavivirusInfluenza VirusHCVDENVHepatitis C virusIsoflavoneViralDenguevirusDNVRNAhepatitisCIRF-3broad-spectrumInhibitorinhibitorinhibit

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