2. Anti-infection Immunology/Inflammation
  3. HCV IFNAR
  4. KIN1400

KIN1400 is a potent IRF3 activator. KIN1400 triggers IRF3-dependent innate immune antiviral genes (RIG-I, MDA5, IFIT1, and Mx1) and IFN-β expression. KIN1400 inhibits WNV and DV, two mosquito-borne members of the Flaviviridae and the genus Flavivirus. KIN1400 also inhibits HCV replication. KIN1400 induces innate antiviral immunity through a MAVS-IRF3 axis.

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KIN1400 Chemical Structure

KIN1400 Chemical Structure

CAS No. : 446826-86-4

Size Price Stock Quantity
1 mg USD 54 In-stock
5 mg USD 225 In-stock
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Based on 1 publication(s) in Google Scholar

KIN1400 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

KIN1400 is a potent IRF3 activator. KIN1400 triggers IRF3-dependent innate immune antiviral genes (RIG-I, MDA5, IFIT1, and Mx1) and IFN-β expression. KIN1400 inhibits WNV and DV, two mosquito-borne members of the Flaviviridae and the genus Flavivirus. KIN1400 also inhibits HCV replication. KIN1400 induces innate antiviral immunity through a MAVS-IRF3 axis[1].

In Vitro

KIN1400 (0-20 μM, 20 h) induces the expression of the innate immune genes RIG-I (DDX58), IFIT1, and Mx1 in a dose-dependent fashion in PMA-differentiated THP-1 cells[1].
KIN1400 (0-20 μM, 24 h) suppresses WNV RNA levels is dose dependent in HEK293 cells, with 2 μM KIN1400 being sufficient to achieve a 50% or greater inhibition of WNV RNA levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIN1400 Related Antibodies
Molecular Weight

449.47

Formula

C24H17F2N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C2N=CC=CC2=CC=C1C(NC3=NC4=CC=CC=C4S3)C5=CC=C(OC(F)F)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (66.75 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2248 mL 11.1242 mL 22.2484 mL
5 mM 0.4450 mL 2.2248 mL 4.4497 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.1%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2248 mL 11.1242 mL 22.2484 mL 55.6211 mL
5 mM 0.4450 mL 2.2248 mL 4.4497 mL 11.1242 mL
10 mM 0.2225 mL 1.1124 mL 2.2248 mL 5.5621 mL
15 mM 0.1483 mL 0.7416 mL 1.4832 mL 3.7081 mL
20 mM 0.1112 mL 0.5562 mL 1.1124 mL 2.7811 mL
25 mM 0.0890 mL 0.4450 mL 0.8899 mL 2.2248 mL
30 mM 0.0742 mL 0.3708 mL 0.7416 mL 1.8540 mL
40 mM 0.0556 mL 0.2781 mL 0.5562 mL 1.3905 mL
50 mM 0.0445 mL 0.2225 mL 0.4450 mL 1.1124 mL
60 mM 0.0371 mL 0.1854 mL 0.3708 mL 0.9270 mL
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KIN1400 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIN1400446826-86-4KIN 1400KIN-1400HCVIFNARHepatitis C virusInterferon-α/β receptorInterferon-alpha/beta receptorHEK293PH5CH8Huh7 cellsWNVDVFlaviviridaeFlavivirusInhibitorinhibitorinhibit

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