Kinetin triphosphate (Synonyms: 6-Fu-ATP; KTP)

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Kinetin triphosphate(6-Fu-ATP; KTP) is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate can be used in Parkinson's disease research.

For research use only. We do not sell to patients.

Kinetin triphosphate Chemical Structure

CAS No. : 1450894-16-2

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Other Forms of Kinetin triphosphate:

Kinetin triphosphate tetrasodium Get quote

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Description

In Vitro

Kinetin triphosphate can act as a phosphate donor for PINK1 to recognize the T257 autophosphorylation site, and can restore the catalytic activity of PINK1 G309D to close to WT levels in HeLa cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

587.27

Formula

C₁₅H₂₀N₅O₁₄P₃

CAS No.

1450894-16-2

SMILES

O=P(O)(O)OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(NCC4=CC=CO4)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nicholas T Hertz, et al. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 2013 Aug 15;154(4):737-47. [Content Brief]

Kinetin triphosphate Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kinetin triphosphate1450894-16-26-Fu-ATP KTPPINK1/ParkinATP analogueParkinson's diseasecatalyticInhibitorinhibitorinhibit

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