2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Apoptosis Cytochrome P450 Caspase Reactive Oxygen Species
  4. Apoptosis inducer 30

Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells apoptosis through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer.

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Apoptosis inducer 30 Chemical Structure

Apoptosis inducer 30 Chemical Structure

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Apoptosis inducer 30 Related Antibodies

Top Publications Citing Use of Products

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells apoptosis through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer[1].

IC50 & Target[1]

Caspase-9

 

Caspase-7

 

In Vitro

Apoptosis inducer 30 inhibits tumor growth, with IC50s of 1.01, 0.91, 0.32, 0.95, 8.09 μM for A549, HepG2, MCF-7, HeLa, MCF-10A cell respectively[1].
Apoptosis inducer 30 (100-500 nM, 48 h) increases Cyt-C levels in the cytoplasm, and activates caspase-9 and caspase-7 in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 30 Related Antibodies
Molecular Weight

882.99

Formula

C52H69BrNO4P
SMILES

CC(C)[C@H](C)/C=C/[C@@H](C)[C@H]1CCC2[C@@]34C=C[C@@]5(OO4)C[C@@H](OC(NCCCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=O)CC[C@]5(C)C3CC[C@@]21C.[Br-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Apoptosis inducer 30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 30Apoptosis inducer30Apoptosis inducer-30ApoptosisCytochrome P450CaspaseReactive Oxygen SpeciesCYPsInhibitorinhibitorinhibit

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