KLD-12 TFA

Cat. No.: HY-P2263A Purity: 95.22%: FAQs
Data Sheet SDS COA Handling Instructions

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KLD-12 TFA is the TFA salt form of KLD-12 (HY-P2263). KLD-12 TFA is a self a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 TFA combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 TFA hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair.

For research use only. We do not sell to patients.

KLD-12 TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of KLD-12 TFA:

KLD-12 Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

KLD-12 TFA forms self-assembled polypeptide with SDF-1, improves the survival of bone marrow stromal cells (BMSCs), promotes osteogenic differentiation of BMSCs and cell migration through Wnt/β-catenin pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KLD-12 TFA (10-250 μg/rat, single dose, injection to infrature site) promotes bone regeneration at the fracture site in a dose-dependent manner in Sprague-Dawley rats model with drill-hole injury in femur^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats model with drill-hole injury in femur^[2]
Dosage:	10-250 μg/rat
Administration:	injection to the fracture site, single dose
Result:	Increased osteoinduction and callus formation.

Molecular Weight

1467.79 (free base)

Formula

C₆₈H₁₂₂N₁₆O₁₉.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2

Sequence Shortening

Ac-KLDLKLDLKLDL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.22%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (401 KB) RP-HPLC (159 KB) MS (70 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs via the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858. [Content Brief]

[2]. Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103. [Content Brief]

[3]. Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001. [Content Brief]

KLD-12 TFA Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KLD-12KLD12KLD 12Othersself-assembling peptideSprague Dawley ratsSDF-1Inhibitorinhibitorinhibit

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