2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12C inhibitor 44

KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo.

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KRAS G12C inhibitor 44 Chemical Structure

KRAS G12C inhibitor 44 Chemical Structure

CAS No. : 2927439-07-2

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KRAS G12C inhibitor 44 Related Antibodies

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Description

KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC50s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo[1].

IC50 & Target[1]

KRas G12C

 

Molecular Weight

579.11

Formula

C31H36ClFN6O2
CAS No.
SMILES

ClC1=C2C([C@]3(CC2)CC4=NC(OC[C@H]5N(CCC5)C)=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C4CC3)=CC=C1
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References
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KRAS G12C inhibitor 44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12C inhibitor 442927439-07-2Rasorally activeCD1 miceMIA PaCA-2H358 cellsanti-proliferationInhibitorinhibitorinhibit

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