KV2 channel inhibitor-1

Name: KV2 channel inhibitor-1
Brand: MedChemExpress
SKU: HY-44153
Rating: 4.5 (1 reviews)

Cat. No.: HY-44153 Purity: 98.46%: FAQs
Data Sheet SDS COA Handling Instructions

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KV2 channel inhibitor-1 is a selective K_V2 channel inhibitor with IC₅₀s of 0.2 μM and 0.41 μM for K_V2.1 and K_V2.2, respectively. KV2 channel inhibitor-1 possesses good selectivity over K_V1.2 (IC₅₀>10 μM). KV2 channel inhibitor-1 is >10-fold selective over Na_V channels and other K_V channels and displays weak activity on Ca_V channels.

For research use only. We do not sell to patients.

KV2 channel inhibitor-1 Chemical Structure

CAS No. : 689297-68-5

Size	Price	Stock	Quantity
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 0.2 μM (KV2.1), 0.41 μM (KV2.2), 12.1 μM (KV1.2), 9.5 μM (KV1.5), >20 μM (KV3.2), 2.9 μM (KV11.1), 6.6 μM (CaV1.2), >10 μM (CaV2.1), >10 μM (CaV2.2), 5.7 μM (CaV2.3), >10 μM (NaV1.5), 8 μM (NaV1.7)^[1]

In Vitro

KV2 channel inhibitor-1 (compound A1; 0.3, 1, 3 μM; 0-3000s) inhibits the K_V current in rat insulinoma INS-1 cells. KV2 channel inhibitor-1 blocks INS-1 K_V current an average of 71% at 0.3 μM and 84% at 3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.89

Formula

C₂₀H₁₇ClN₄OS

CAS No.

689297-68-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C2N=C(C3=CSC=N3)NC2=C1)CC(C)C4=CC=CC(Cl)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (629.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5196 mL	12.5979 mL	25.1959 mL
5 mM	0.5039 mL	2.5196 mL	5.0392 mL
10 mM	0.2520 mL	1.2598 mL	2.5196 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.46%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (284 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. James Herrington, et al. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5196 mL	12.5979 mL	25.1959 mL	62.9897 mL
	5 mM	0.5039 mL	2.5196 mL	5.0392 mL	12.5979 mL
	10 mM	0.2520 mL	1.2598 mL	2.5196 mL	6.2990 mL
	15 mM	0.1680 mL	0.8399 mL	1.6797 mL	4.1993 mL
	20 mM	0.1260 mL	0.6299 mL	1.2598 mL	3.1495 mL
	25 mM	0.1008 mL	0.5039 mL	1.0078 mL	2.5196 mL
	30 mM	0.0840 mL	0.4199 mL	0.8399 mL	2.0997 mL
	40 mM	0.0630 mL	0.3149 mL	0.6299 mL	1.5747 mL
	50 mM	0.0504 mL	0.2520 mL	0.5039 mL	1.2598 mL
	60 mM	0.0420 mL	0.2100 mL	0.4199 mL	1.0498 mL
	80 mM	0.0315 mL	0.1575 mL	0.3149 mL	0.7874 mL
	100 mM	0.0252 mL	0.1260 mL	0.2520 mL	0.6299 mL