2. Apoptosis MAPK/ERK Pathway
  3. Necroptosis RIP kinase Mixed Lineage Kinase
  4. KWCN-41

KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. KWCN-41 specifically inhibits cell necrosis but does not inhibit apoptosis. KWCN-41 also has anti-inflammatory effects.

For research use only. We do not sell to patients.

KWCN-41 Chemical Structure

KWCN-41 Chemical Structure

CAS No. : 2913223-17-1

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Based on 1 publication(s) in Google Scholar

KWCN-41 Related Antibodies

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Description

KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. KWCN-41 specifically inhibits cell necrosis but does not inhibit apoptosis. KWCN-41 also has anti-inflammatory effects[1].

IC50 & Target[1]

RIPK1

88 nM (IC50)

In Vitro

KWCN-41 (10, 50, 250 nM; 1 h) inhibits L929 cell necroptosis in a dosedependent manner and increases the number of cells in the viable cell zone[1].
KWCN-41 (10, 50, 250 nM; 0.5, 1.5, 2.5 h) inhibits the phosphorylation of RIPK1/3 and MLKL in L929 cells[1].
KWCN-41 (0-10 μM) inhibits TZ-induced necroptosis of L929 cells in a dose-dependent manner and similarly protects cells from TSZ (TNF-α, Smac mimetic, and z-VAD-FMK)-induced necroptosis of HT-29 and U937 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KWCN-41 Related Antibodies

Cell Viability Assay[1]

Cell Line: L929 cells
Concentration: 10, 50, 250 nM
Incubation Time: 1 h
Result: Inhibited L929 cell necroptosis in a Dosedependent manner and increased the number of cells in the viable cell zone.
In Vivo

KWCN-41 (10, 25, 40 mg/kg; i.p.; 72 h) dose-dependently inhibits TNF-α-induced death and improves survival in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inflammatory mouse model[1]
Dosage: 10, 25, 40 mg/kg
Administration: i.p.; dissolved in saline containing 10% DMSO and 20% Tween80; 72 h
Result: At 25, 40 mg/kg completely inhibited TNF-α induced death in mice, achieving 100% survival compared to 75% survival at 10 mg/kg.
Molecular Weight

307.35

Formula

C18H17N3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCOCC1)C2=CC=C(C3=CC4=C(N3)N=CC=C4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (325.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2536 mL 16.2681 mL 32.5362 mL
5 mM 0.6507 mL 3.2536 mL 6.5072 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2536 mL 16.2681 mL 32.5362 mL 81.3405 mL
5 mM 0.6507 mL 3.2536 mL 6.5072 mL 16.2681 mL
10 mM 0.3254 mL 1.6268 mL 3.2536 mL 8.1340 mL
15 mM 0.2169 mL 1.0845 mL 2.1691 mL 5.4227 mL
20 mM 0.1627 mL 0.8134 mL 1.6268 mL 4.0670 mL
25 mM 0.1301 mL 0.6507 mL 1.3014 mL 3.2536 mL
30 mM 0.1085 mL 0.5423 mL 1.0845 mL 2.7113 mL
40 mM 0.0813 mL 0.4067 mL 0.8134 mL 2.0335 mL
50 mM 0.0651 mL 0.3254 mL 0.6507 mL 1.6268 mL
60 mM 0.0542 mL 0.2711 mL 0.5423 mL 1.3557 mL
80 mM 0.0407 mL 0.2034 mL 0.4067 mL 1.0168 mL
100 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.8134 mL
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KWCN-41 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KWCN-412913223-17-1KWCN41KWCN 41NecroptosisRIP kinaseMixed Lineage KinaseReceptor-interacting protein kinasesRIPKMLKsRIPK1 kinasecell necrosisanti-inflammatoryInhibitorinhibitorinhibit

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