2. GPCR/G Protein
  3. Angiotensin Receptor
  4. L-162313

L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth.

For research use only. We do not sell to patients.

L-162313 Chemical Structure

L-162313 Chemical Structure

CAS No. : 151488-11-8

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Based on 1 publication(s) in Google Scholar

L-162313 Related Antibodies

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Description

L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth[1].

Cellular Effect
Cell Line Type Value Description References
COS-7 IC50
1.1 nM
Compound: L-162313
Displacement of [125I]angiotensin 2 from rat AT1 receptor expressed in african green monkey COS7 cells after 24 hrs
Displacement of [125I]angiotensin 2 from rat AT1 receptor expressed in african green monkey COS7 cells after 24 hrs
[PMID: 20493713]
COS-7 IC50
2 nM
Compound: L-162313
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
[PMID: 20493713]
Molecular Weight

582.78

Formula

C30H38N4O4S2
CAS No.
SMILES

O=C(NS(=O)(C1=C(C2=CC=C(CN3C4=NC(C)=CC(C)=C4N=C3CC)C=C2)C=C(CC(C)C)S1)=O)OCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-162313 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-162313151488-11-8L162313L 162313Angiotensin Receptornon-peptidevasoconstrictionaldosterone releasecardiovascular growthInhibitorinhibitorinhibit

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