2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. L-748328

L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes.

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L-748328 Chemical Structure

L-748328 Chemical Structure

CAS No. : 244192-93-6

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L-748328 Related Antibodies

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Description

L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes[1].

IC50 & Target[1]

β3 adrenoceptor

3.7 nM (Ki)

Molecular Weight

505.61

Formula

C23H27N3O6S2
CAS No.
SMILES

O=S(C1=CC=CC(OC[C@H](CNCCC2=CC=C(C=C2)NS(=O)(C3=CC=CC=C3)=O)O)=C1)(N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-748328 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-748328244192-93-6L748328L 748328Adrenergic ReceptorBeta ReceptorSelectiveantagonistCHO cellsadipocytesadrenergic receptorsInhibitorinhibitorinhibit

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