L-796568 free base

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L-796568 free base is a β(3)-adrenergic receptor agonist. L-796568 free base can be used for the research of obesity.

For research use only. We do not sell to patients.

L-796568 free base Chemical Structure

CAS No. : 211031-01-5

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

L-796568 free base is a β(3)-adrenergic receptor agonist. L-796568 free base can be used for the research of obesity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.003 μM Compound: 2	Agonist activity (EC50) was assessed by measuring cAMP levels in CHO cells expressing cloned human Beta-3 adrenergic receptor Agonist activity (EC50) was assessed by measuring cAMP levels in CHO cells expressing cloned human Beta-3 adrenergic receptor	10.1016/s0960-894x(04)00462-7
CHO	EC₅₀	0.43 nM Compound: 3; MK-0634	Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	[PMID: 26709102]
CHO	EC₅₀	17 nM Compound: 3; MK-0634	Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum Agonist activity at rhesus monkey beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum	[PMID: 26709102]
CHO	EC₅₀	2 nM Compound: 3; MK-0634	Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	[PMID: 26709102]
CHO	IC₅₀	2.3 μM Compound: 1	Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counter Displacement of [125I]cyanopindolol from human beta 2 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counter	[PMID: 20181479]
CHO	IC₅₀	2.3 μM Compound: 1	Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counter Displacement of [125I]cyanopindolol from human beta 1 adrenergic receptor expressed in CHO cells at 10 uM after 3 to 4 hrs by scintillation counter	[PMID: 20181479]
CHO	EC₅₀	25 nM Compound: 3; MK-0634	Agonist activity at dog beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay Agonist activity at dog beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	[PMID: 26709102]
CHO	EC₅₀	3.6 nM Compound: 1	Agonistic activity at human beta3 adrenergic receptor expressed in CHO cells assessed as amount of cAMP released after 1 hr by fluorescence resonance energy transfer immuno assay Agonistic activity at human beta3 adrenergic receptor expressed in CHO cells assessed as amount of cAMP released after 1 hr by fluorescence resonance energy transfer immuno assay	[PMID: 20181479]
CHO	EC₅₀	3400 nM Compound: 3; MK-0634	Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay Agonist activity at rat beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	[PMID: 26709102]
CHO	EC₅₀	7.9 nM Compound: 3; MK-0634	Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay in presence of 40% serum	[PMID: 26709102]
HEK293	IC₅₀	5 μM Compound: 3; MK-0634	Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plate reader analysis Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plate reader analysis	[PMID: 26709102]

Molecular Weight

624.70

Formula

C₃₁H₂₇F₃N₄O₃S₂

CAS No.

211031-01-5

SMILES

O=S(C1=CC=C(C=C1)C2=NC(C3=CC=C(C=C3)C(F)(F)F)=CS2)(NC4=CC=C(C=C4)CCNC[C@@H](C5=CC=CN=C5)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Thomas M Larsen, et al. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr. 2002 Oct;76(4):780-8. [Content Brief]