2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Carnitine hydrochloride

L-Carnitine hydrochloride  (Synonyms: (R)-Carnitine hydrochloride; Levocarnitine hydrochloride)

Cat. No.: HY-B2246 Purity: ≥98.0%
SDS COA Handling Instructions

Molarity Calculator

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.

For research use only. We do not sell to patients.

L-Carnitine hydrochloride Chemical Structure

L-Carnitine hydrochloride Chemical Structure

CAS No. : 6645-46-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
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100 mg USD 70 In-stock
500 mg USD 180 In-stock
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Based on 13 publication(s) in Google Scholar

Other Forms of L-Carnitine hydrochloride:

L-Carnitine hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vivo

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride) (125, 250 mg/kg; i.p.) has a more pronounced bronchodilator effect in this chronic murine asthma model, and decreases urinary LTE4 excretion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-weeks-old and weighed 28-30g BALB/c mice[2]
Dosage: 125, 250 mg/kg
Administration: i.p.
Result: SaO2 increased significantly at 250 mg/kg and decreased urinaryLTE4 excretion.
Clinical Trial
Molecular Weight

197.66

Formula

C7H16ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[N+](C)(C)C[C@H](O)CC(O)=O.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 175 mg/mL (885.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0592 mL 25.2960 mL 50.5919 mL
5 mM 1.0118 mL 5.0592 mL 10.1184 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (252.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (246 KB) HNMR (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0592 mL 25.2960 mL 50.5919 mL 126.4798 mL
5 mM 1.0118 mL 5.0592 mL 10.1184 mL 25.2960 mL
10 mM 0.5059 mL 2.5296 mL 5.0592 mL 12.6480 mL
15 mM 0.3373 mL 1.6864 mL 3.3728 mL 8.4320 mL
20 mM 0.2530 mL 1.2648 mL 2.5296 mL 6.3240 mL
25 mM 0.2024 mL 1.0118 mL 2.0237 mL 5.0592 mL
30 mM 0.1686 mL 0.8432 mL 1.6864 mL 4.2160 mL
40 mM 0.1265 mL 0.6324 mL 1.2648 mL 3.1620 mL
50 mM 0.1012 mL 0.5059 mL 1.0118 mL 2.5296 mL
60 mM 0.0843 mL 0.4216 mL 0.8432 mL 2.1080 mL
80 mM 0.0632 mL 0.3162 mL 0.6324 mL 1.5810 mL
100 mM 0.0506 mL 0.2530 mL 0.5059 mL 1.2648 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Carnitine hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Carnitine6645-46-1(R)-CarnitineLevocarnitineEndogenous Metabolitepolarzwitterionco-factorlong-chainfattyacidsmitochondrialmatrixantioxidant metabolismInhibitorinhibitorinhibit

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