L-NIL dihydrochloride

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L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC₅₀ of 3.3 μM for miNOS.

For research use only. We do not sell to patients.

L-NIL dihydrochloride Chemical Structure

CAS No. : 159190-45-1

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Other In-stock Forms of L-NIL dihydrochloride:

L-NIL

Other Forms of L-NIL dihydrochloride:

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L-NIL hydrochloride Get quote

7 Publications Citing Use of MCE L-NIL dihydrochloride

•Exp Eye Res. 2024 Apr 5:243:109886. [Abstract]

: L-NIL dihydrochloride purchased from MedChemExpress. Usage Cited in: J Adv Res. 5 March 2022.; Inhibiting iNOS with L-NIL (10 μM) blunted the adverse effect of iNOS expression in cardiomyocytes.

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
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Description

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC₅₀ of 3.3 μM for miNOS^[1]^[2]^[3].

IC₅₀ & Target

IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)^[3].

In Vitro

L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC₅₀ values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Balb/c (20-25 g)^[1].
Dosage:	10 and 30 mg/kg.
Administration:	Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
Result:	Led to a negligible increase in plasma NGAL compared to sham mice. Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.

Molecular Weight

260.16

Formula

C₈H₁₉Cl₂N₃O₂

CAS No.

159190-45-1

SMILES

N[C@@H](CCCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. [Content Brief]

[2]. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. [Content Brief]

[3]. W M Moore, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. [Content Brief]