2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. L-Threonolactone

L-Threonolactone  (Synonyms: (3R,4S)-3,4-Dihydroxyoxolan-2-one)

Cat. No.: HY-W357137
Handling Instructions Technical Support

L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

L-Threonolactone Chemical Structure

L-Threonolactone Chemical Structure

CAS No. : 21730-93-8

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Based on 1 publication(s) in Google Scholar

L-Threonolactone Related Antibodies

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Description

L-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Molecular Weight

118.09

Formula

C4H6O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](CO1)[C@@H](O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (705.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.4681 mL 42.3406 mL 84.6812 mL
5 mM 1.6936 mL 8.4681 mL 16.9362 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.4681 mL 42.3406 mL 84.6812 mL 211.7029 mL
5 mM 1.6936 mL 8.4681 mL 16.9362 mL 42.3406 mL
10 mM 0.8468 mL 4.2341 mL 8.4681 mL 21.1703 mL
15 mM 0.5645 mL 2.8227 mL 5.6454 mL 14.1135 mL
20 mM 0.4234 mL 2.1170 mL 4.2341 mL 10.5851 mL
25 mM 0.3387 mL 1.6936 mL 3.3872 mL 8.4681 mL
30 mM 0.2823 mL 1.4114 mL 2.8227 mL 7.0568 mL
40 mM 0.2117 mL 1.0585 mL 2.1170 mL 5.2926 mL
50 mM 0.1694 mL 0.8468 mL 1.6936 mL 4.2341 mL
60 mM 0.1411 mL 0.7057 mL 1.4114 mL 3.5284 mL
80 mM 0.1059 mL 0.5293 mL 1.0585 mL 2.6463 mL
100 mM 0.0847 mL 0.4234 mL 0.8468 mL 2.1170 mL
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L-Threonolactone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Threonolactone21730-93-8(3R,4S)-3,4-Dihydroxyoxolan-2-oneNucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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