2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. Labuxtinib

Labuxtinib is c-kit tyrosine kinase inhibitor.

For research use only. We do not sell to patients.

Labuxtinib Chemical Structure

Labuxtinib Chemical Structure

CAS No. : 1426449-01-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 473 In-stock
Solution
10 mM * 1 mL in DMSO USD 473 In-stock
Solid
1 mg USD 172 In-stock
5 mg USD 430 In-stock
10 mg USD 690 In-stock
25 mg USD 1380 In-stock
50 mg USD 2200 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Labuxtinib is c-kit tyrosine kinase inhibitor[1].

Molecular Weight

377.37

Formula

C20H16FN5O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC1=CC=C(C2=NOC([C@@H]3[C@H](C3)F)=N2)C=C1NC(C4=CN=C5N4C=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (331.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6499 mL 13.2496 mL 26.4992 mL
5 mM 0.5300 mL 2.6499 mL 5.2998 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.76%

COA (251 KB) HNMR (274 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6499 mL 13.2496 mL 26.4992 mL 66.2480 mL
5 mM 0.5300 mL 2.6499 mL 5.2998 mL 13.2496 mL
10 mM 0.2650 mL 1.3250 mL 2.6499 mL 6.6248 mL
15 mM 0.1767 mL 0.8833 mL 1.7666 mL 4.4165 mL
20 mM 0.1325 mL 0.6625 mL 1.3250 mL 3.3124 mL
25 mM 0.1060 mL 0.5300 mL 1.0600 mL 2.6499 mL
30 mM 0.0883 mL 0.4417 mL 0.8833 mL 2.2083 mL
40 mM 0.0662 mL 0.3312 mL 0.6625 mL 1.6562 mL
50 mM 0.0530 mL 0.2650 mL 0.5300 mL 1.3250 mL
60 mM 0.0442 mL 0.2208 mL 0.4417 mL 1.1041 mL
80 mM 0.0331 mL 0.1656 mL 0.3312 mL 0.8281 mL
100 mM 0.0265 mL 0.1325 mL 0.2650 mL 0.6625 mL
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Labuxtinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Labuxtinib1426449-01-5c-KitSCFRCD117Inhibitorinhibitorinhibit

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