2. Cytoskeleton
  3. Gap Junction Protein
  4. Larazotide

Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Larazotide Chemical Structure

Larazotide Chemical Structure

CAS No. : 258818-34-7

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10 mg USD 160 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Larazotide:

Larazotide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection[1][2].

In Vitro

Larazotide (1-100 μM; 5 d) affects Vero cell growth[1].
Larazotide (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively[1].
Larazotide (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells[2].
Larazotide (100 μM; 3 h) inhibits gliadin translocation across Caco-2 monolayers[2].
Larazotide (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Larazotide Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Vero cell line
Concentration: 1-100 μM
Incubation Time: 5 days
Result: Inhibited Vero cell growth with an CC50 value of 82.5 μM.
In Vivo

Larazotide (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HLA-HCD4/DQ8 double transgenic mice[2]
Dosage: 250 μg
Administration: Intraperitoneal injection; 250 μg twice a week for 7 weeks
Result: Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels.
Clinical Trial
Molecular Weight

725.83

Formula

C32H55N9O10
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 27.5 mg/mL (37.89 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3777 mL 6.8887 mL 13.7773 mL
5 mM 0.2755 mL 1.3777 mL 2.7555 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3777 mL 6.8887 mL 13.7773 mL 34.4433 mL
5 mM 0.2755 mL 1.3777 mL 2.7555 mL 6.8887 mL
10 mM 0.1378 mL 0.6889 mL 1.3777 mL 3.4443 mL
15 mM 0.0918 mL 0.4592 mL 0.9185 mL 2.2962 mL
20 mM 0.0689 mL 0.3444 mL 0.6889 mL 1.7222 mL
25 mM 0.0551 mL 0.2755 mL 0.5511 mL 1.3777 mL
30 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1481 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Larazotide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Larazotide258818-34-7Gap Junction ProteinpeptideoralVZVVeroceliacinfectionInhibitorinhibitorinhibit

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