2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. Akt Src ERK
  4. Larixol

Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC50: 1.98 μM), cathepsin G release (IC50: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants.

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Larixol Chemical Structure

Larixol Chemical Structure

CAS No. : 1438-66-0

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Based on 1 publication(s) in Google Scholar

Larixol Related Antibodies

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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Lck Fyn Blk

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ERK ERK1 ERK2 ERK5 ERK8

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Description

Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC50: 1.98 μM), cathepsin G release (IC50: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants[1][2].

IC50 & Target

(+)-Larixol[1]
Molecular Weight

306.48

Formula

C20H34O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@](C(C)(CCC2)C)([H])[C@H](CC([C@@H]1CC[C@](C)(O)C=C)=C)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (163.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2629 mL 16.3143 mL 32.6286 mL
5 mM 0.6526 mL 3.2629 mL 6.5257 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.52%

SDS (393 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2629 mL 16.3143 mL 32.6286 mL 81.5714 mL
5 mM 0.6526 mL 3.2629 mL 6.5257 mL 16.3143 mL
10 mM 0.3263 mL 1.6314 mL 3.2629 mL 8.1571 mL
15 mM 0.2175 mL 1.0876 mL 2.1752 mL 5.4381 mL
20 mM 0.1631 mL 0.8157 mL 1.6314 mL 4.0786 mL
25 mM 0.1305 mL 0.6526 mL 1.3051 mL 3.2629 mL
30 mM 0.1088 mL 0.5438 mL 1.0876 mL 2.7190 mL
40 mM 0.0816 mL 0.4079 mL 0.8157 mL 2.0393 mL
50 mM 0.0653 mL 0.3263 mL 0.6526 mL 1.6314 mL
60 mM 0.0544 mL 0.2719 mL 0.5438 mL 1.3595 mL
80 mM 0.0408 mL 0.2039 mL 0.4079 mL 1.0196 mL
100 mM 0.0326 mL 0.1631 mL 0.3263 mL 0.8157 mL
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Larixol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Larixol1438-66-0(+)-LarixolAktSrcERKPKBProtein kinase BExtracellular signal regulated kinasesEuphorbia formosanaGi-proteinNeutrophilfMLPInhibitorinhibitorinhibit

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