2. PI3K/Akt/mTOR Metabolic Enzyme/Protease GPCR/G Protein
  3. PI3K Lipase G Protein-coupled Receptor Kinase (GRK)
  4. LAS195319

LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

For research use only. We do not sell to patients.

LAS195319 Chemical Structure

LAS195319 Chemical Structure

CAS No. : 1605328-04-8

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LAS195319 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)[1].

Molecular Weight

594.65

Formula

C29H26N10O3S
CAS No.
SMILES

O=S(N)(NC1=CC2=C(C(C3=CNC4=NC=NC(N[C@H](C(N(C5=CC=CC=C5)C6=O)=NN7C6=C(C)C=C7)C)=C43)=C1)C=CN2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LAS195319 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAS1953191605328-04-8LAS 195319LAS-195319PI3KLipaseG Protein-coupled Receptor Kinase (GRK)Phosphoinositide 3-kinaseorally activePI3Kδproteinslipid kinasesGPCRsneutrophil and eosinophil infiltrationrespiratory diseasesInhibitorinhibitorinhibit

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