LAS195319

Cat. No.: HY-123862: FAQs
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LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC₅₀ value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).

For research use only. We do not sell to patients.

LAS195319 Chemical Structure

CAS No. : 1605328-04-8

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Description	LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC₅₀ value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)^[1].
Molecular Weight	594.65
Formula	C₂₉H₂₆N₁₀O₃S
CAS No.	1605328-04-8
SMILES	O=S(N)(NC1=CC2=C(C(C3=CNC4=NC=NC(N[C@H](C(N(C5=CC=CC=C5)C6=O)=NN7C6=C(C)C=C7)C)=C43)=C1)C=CN2)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Erra M, et al. Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases. J Med Chem. 2018 Nov 8;61(21):9551-9567. [Content Brief]

LAS195319 Related Classifications

Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAS1953191605328-04-8LAS 195319LAS-195319PI3KLipaseG Protein-coupled Receptor Kinase (GRK)Phosphoinositide 3-kinaseorally activePI3Kδproteinslipid kinasesGPCRsneutrophil and eosinophil infiltrationrespiratory diseasesInhibitorinhibitorinhibit

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LAS195319

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