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  4. Laurotetanine

Laurotetanine  (Synonyms: (+)-Laurotetanine)

Cat. No.: HY-117616
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Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.

For research use only. We do not sell to patients.

Laurotetanine Chemical Structure

Laurotetanine Chemical Structure

CAS No. : 128-76-7

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Laurotetanine Related Antibodies

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Description

Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
> 10 μM
Compound: 11
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay
[PMID: 28499733]
In Vivo

Laurotetanine ((+)-Laurotetanine; 20-60 mg/kg; p.o.; daily, for 21 d; Sprague Dawley (SD) rats) has anti-asthmatic effect in rats by down-regulating MUC5AC and NF-κB signaling pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (SD) rats (180-220g) [1]
Dosage: 20, 40, and 60 mg/kg
Administration: Oral administration; daily, for 21 days
Result: Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages.
Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ.
Reduced serum IgE and histamine.
Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
Molecular Weight

327.37

Formula

C19H21NO4
CAS No.
SMILES

OC1=C(C=C2C3=C4C(CCN[C@]4(CC2=C1)[H])=CC(OC)=C3OC)OC
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Laurotetanine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laurotetanine128-76-7(+)-LaurotetanineNF-κBNuclear factor-κBNuclear factor-kappaBisoquinoline alkaloidasthmaticMUC5ACIgEhistamineinflammatory reactionsInhibitorinhibitorinhibit

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