Lauroyl-L-carnitine chloride

Cat. No.: HY-130321 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lauroyl-L-carnitine chloride can be used as an absorption enhancer.

For research use only. We do not sell to patients.

Lauroyl-L-carnitine chloride Chemical Structure

CAS No. : 6919-91-1

Size	Price	Stock
5 mg	USD 80	Ask For Quote & Lead Time
10 mg	USD 130	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Lauroyl-L-carnitine chloride:

Lauroyl-L-carnitine-d₃ chloride Get quote
Lauroyl-L-carnitine-d₉ chloride Get quote
Lauroyl-L-carnitine-d₃ hydrochloride Get quote

1 Publications Citing Use of MCE Lauroyl-L-carnitine chloride

•iScience. 2024 Jul 26.

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Biological Activity
Purity & Documentation
References
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Description

Lauroyl-L-carnitine chloride can be used as an absorption enhancer^[1].

Molecular Weight

379.96

Formula

C₁₉H₃₈ClNO₄

CAS No.

6919-91-1

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCC(O[C@H](CC(O)=O)C[N+](C)(C)C)=O.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (131.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6319 mL	13.1593 mL	26.3186 mL
5 mM	0.5264 mL	2.6319 mL	5.2637 mL
10 mM	0.2632 mL	1.3159 mL	2.6319 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.29 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.29 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (3.29 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (243 KB) HNMR (137 KB) OR (235 KB)

Handling Instructions (2659 KB)

References

[1]. Fu, Ling, et al. An oral pharmaceutical composition of a peptide amide compound (I, compound A). The present invention further relates to a method for preparing an oral pharmaceutical composition, and the use of the oral pharmaceutical composition in preparing a drug for treating diseases or conditions related to the κ-opioid receptor. China, WO2021185265. 2021-09-23

[2]. Ling Fu, et al. Oral pharmaceutical composition. Patent WO2021185265A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6319 mL	13.1593 mL	26.3186 mL	65.7964 mL
	5 mM	0.5264 mL	2.6319 mL	5.2637 mL	13.1593 mL
	10 mM	0.2632 mL	1.3159 mL	2.6319 mL	6.5796 mL
	15 mM	0.1755 mL	0.8773 mL	1.7546 mL	4.3864 mL
	20 mM	0.1316 mL	0.6580 mL	1.3159 mL	3.2898 mL
	25 mM	0.1053 mL	0.5264 mL	1.0527 mL	2.6319 mL
	30 mM	0.0877 mL	0.4386 mL	0.8773 mL	2.1932 mL
	40 mM	0.0658 mL	0.3290 mL	0.6580 mL	1.6449 mL
	50 mM	0.0526 mL	0.2632 mL	0.5264 mL	1.3159 mL
	60 mM	0.0439 mL	0.2193 mL	0.4386 mL	1.0966 mL
	80 mM	0.0329 mL	0.1645 mL	0.3290 mL	0.8225 mL
	100 mM	0.0263 mL	0.1316 mL	0.2632 mL	0.6580 mL