2. Others PI3K/Akt/mTOR
  3. Isotope-Labeled Compounds PI3K
  4. Leniolisib-d5

Leniolisib-d5  (Synonyms: CDZ173-d5)

Cat. No.: HY-17635S Purity: 98.78%
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Leniolisib-d5 is a deuterated labeled Leniolisib. Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

For research use only. We do not sell to patients.

Leniolisib-d<sub>5</sub> Chemical Structure

Leniolisib-d5 Chemical Structure

Size Price Stock Quantity
1 mg USD 1030 In-stock
5 mg USD 2279 In-stock
10 mg USD 3647 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Leniolisib-d5:

Leniolisib-d5 Related Antibodies

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Leniolisib-d5 is a deuterated labeled Leniolisib[1]. Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Expression of APDS mutant p110δ in cell lines and patient-derived lymphocytes lead to increased pathway activity, measured as phosphorylation of AKT or S6, which is suppressed by leniolisib in a concentration dependent way[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leniolisib-d5 Related Antibodies
In Vivo

Oral leniolisib lead to a dose-dependent reduction in PI3K/AKT pathway activity and resolve the immune dysregulation with normalization of circulating transitional and na?ve B cells and reduction in PD-1+CD4+ and senescent CD57+CD8+ T cells. After 12 weeks of treatment, all patients show amelioration of lymphoproliferation with lymph node sizes and spleen volumes reduced by 39% (mean, range 26-57%) and 40% (mean, range: 13-65%), respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

455.49

Formula

C21H20D5F3N6O2
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C(F)(F)F)C=C(N2CC(C(N[C@H]3CCN(C(C([2H])([2H])C([2H])([2H])[2H])=O)C3)=NC=N4)=C4CC2)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1954 mL 10.9772 mL 21.9544 mL
5 mM 0.4391 mL 2.1954 mL 4.3909 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1954 mL 10.9772 mL 21.9544 mL 54.8859 mL
5 mM 0.4391 mL 2.1954 mL 4.3909 mL 10.9772 mL
10 mM 0.2195 mL 1.0977 mL 2.1954 mL 5.4886 mL
15 mM 0.1464 mL 0.7318 mL 1.4636 mL 3.6591 mL
20 mM 0.1098 mL 0.5489 mL 1.0977 mL 2.7443 mL
25 mM 0.0878 mL 0.4391 mL 0.8782 mL 2.1954 mL
30 mM 0.0732 mL 0.3659 mL 0.7318 mL 1.8295 mL
40 mM 0.0549 mL 0.2744 mL 0.5489 mL 1.3721 mL
50 mM 0.0439 mL 0.2195 mL 0.4391 mL 1.0977 mL
60 mM 0.0366 mL 0.1830 mL 0.3659 mL 0.9148 mL
80 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6861 mL
100 mM 0.0220 mL 0.1098 mL 0.2195 mL 0.5489 mL
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Leniolisib-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leniolisib-d5CDZ173-d5Isotope-Labeled CompoundsPI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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