2. Protein Tyrosine Kinase/RTK
  3. VEGFR FGFR PDGFR c-Kit RET
  4. Lenvatinib-d4

Lenvatinib-d4  (Synonyms: E7080-d4)

Cat. No.: HY-10981S Purity: 99.59%
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Lenvatinib-d4 is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

For research use only. We do not sell to patients.

Lenvatinib-d<sub>4</sub> Chemical Structure

Lenvatinib-d4 Chemical Structure

CAS No. : 2264050-65-7

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500 μg USD 300 In-stock
1 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Lenvatinib-d4:

Lenvatinib-d4 Related Antibodies

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

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PDGFR PDGFRβ PDGFRα

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Description

Lenvatinib-d4 is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lenvatinib-d4 Related Antibodies
Molecular Weight

430.88

Formula

C21H15D4ClN4O4
CAS No.
Unlabeled CAS

417716-92-8
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC4C([2H])(C4([2H])[2H])[2H])=O)C(Cl)=C3)C2=C1)N
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 12.78 mg/mL (29.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 12.78 mg/mL (29.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3208 mL 11.6042 mL 23.2083 mL
5 mM 0.4642 mL 2.3208 mL 4.6417 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.3208 mL 11.6042 mL 23.2083 mL 58.0208 mL
5 mM 0.4642 mL 2.3208 mL 4.6417 mL 11.6042 mL
10 mM 0.2321 mL 1.1604 mL 2.3208 mL 5.8021 mL
15 mM 0.1547 mL 0.7736 mL 1.5472 mL 3.8681 mL
20 mM 0.1160 mL 0.5802 mL 1.1604 mL 2.9010 mL
25 mM 0.0928 mL 0.4642 mL 0.9283 mL 2.3208 mL
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Lenvatinib-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenvatinib-d42264050-65-7E7080-d4VEGFRFGFRPDGFRc-KitRETVascular endothelial growth factor receptorFibroblast growth factor receptorPlatelet-derived growth factor receptorSCFRCD117Inhibitorinhibitorinhibit

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