2. Metabolic Enzyme/Protease Others Autophagy
  3. Isotope-Labeled Compounds Cytochrome P450 Autophagy
  4. Letrozole-d4

Letrozole-d4 (CGS 20267-d4) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].

For research use only. We do not sell to patients.

Letrozole-d<sub>4</sub> Chemical Structure

Letrozole-d4 Chemical Structure

CAS No. : 1133712-96-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Letrozole-d4:

Letrozole-d4 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Letrozole-d4 (CGS 20267-d4) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].

IC50 & Target

Aromatase

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Letrozole-d4 Related Antibodies
Molecular Weight

289.33

Formula

C17H7D4N5
CAS No.
Unlabeled CAS

112809-51-5
Appearance

Solid

Color

White to off-white

SMILES

C(C1=C(C(=C(C#N)C(=C1[2H])[2H])[2H])[2H])(C2=CC=C(C#N)C=C2)N3C=NC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 16 mg/mL (55.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 16 mg/mL (55.30 mM)

DMF : ≥ 16 mg/mL (55.30 mM)

DMSO : ≥ 16 mg/mL (55.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF:PBS (pH 7.2) (1:9) : ≥ 0.1 mg/mL (0.35 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4563 mL 17.2813 mL 34.5626 mL
5 mM 0.6913 mL 3.4563 mL 6.9125 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF / DMF / DMSO 1 mM 3.4563 mL 17.2813 mL 34.5626 mL 86.4065 mL
5 mM 0.6913 mL 3.4563 mL 6.9125 mL 17.2813 mL
10 mM 0.3456 mL 1.7281 mL 3.4563 mL 8.6407 mL
15 mM 0.2304 mL 1.1521 mL 2.3042 mL 5.7604 mL
20 mM 0.1728 mL 0.8641 mL 1.7281 mL 4.3203 mL
25 mM 0.1383 mL 0.6913 mL 1.3825 mL 3.4563 mL
30 mM 0.1152 mL 0.5760 mL 1.1521 mL 2.8802 mL
40 mM 0.0864 mL 0.4320 mL 0.8641 mL 2.1602 mL
50 mM 0.0691 mL 0.3456 mL 0.6913 mL 1.7281 mL
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Letrozole-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Letrozole-d41133712-96-5Isotope-Labeled CompoundsCytochrome P450AutophagyCYPsInhibitorinhibitorinhibit

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